BRAIN and NERVE－神経研究の進歩70巻4号

2018年04月発行

増大特集 Antibody Update 2018

視神経脊髄炎関連疾患と自己抗体

著者： 中島一郎¹ 赤石哲也²

所属機関： ¹東北医科薬科大学医学部老年神経内科学 ²国立病院機構米沢病院神経内科

ページ範囲：P.297 - P.304

文献概要

視神経脊髄炎（NMO）は従来，多発性硬化症の亜型として考えられていたが，2004年に特異的な自己抗体NMO-IgGが発見されて以来，独立した疾患概念として確立されてきた。また，2012年には抗ミエリンオリゴデンドロサイト糖蛋白（MOG）抗体が関与する視神経脊髄炎関連疾患が報告され，抗MOG抗体が陽性の症例の中に視神経脊髄炎と類似の症状を呈するものが含まれていることも判明している。

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