BRAIN and NERVE－神経研究の進歩70巻4号

2018年04月発行

増大特集 Antibody Update 2018

電位依存性カリウムチャネル（VGKC）複合体抗体関連疾患up to date

著者： 渡邊修¹

所属機関： ¹鹿児島市立病院神経内科

ページ範囲：P.315 - P.328

文献概要

電位依存性カリウムチャネル（VGKC）複合体抗体は，アイザックス症候群，モルヴァン症候群，さらに近時記憶障害とてんかんを主張とする辺縁系脳炎の病態関連抗体である。VGKC複合体の主要抗原はLGI1（leucine-rich glioma inactivated protein 1）とCaspr2（contactin-associated protein 2）である。これらに対する抗体が陰性の場合，VGKC複合体抗体が細胞内ドメインに反応しており，病態には直接関連はない。

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