BRAIN and NERVE－神経研究の進歩70巻4号

2018年04月発行

増大特集 Antibody Update 2018

自己免疫性大脳基底核障害と自己抗体

著者： 佐久間啓¹

所属機関： ¹公益財団法人東京都医学総合研究所脳発達・神経再生研究分野

ページ範囲：P.363 - P.369

文献概要

自己免疫性大脳基底核障害とは，大脳基底核の病変に伴い運動異常症を呈し，自己免疫学的機序の関与が推定される病態である。運動異常症を呈する自己免疫性脳炎としては抗NMDA受容体脳炎の頻度が最も高いが，抗リン脂質抗体症候群などとの鑑別も必要である。小児ではSydenham舞踏病や抗ドパミンD2受容体抗体関連脳炎などの疾患も知られている。一部の例では大脳基底核抗原に対する自己抗体が検出される。

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