BRAIN and NERVE－神経研究の進歩70巻4号

2018年04月発行

増大特集 Antibody Update 2018

ギラン・バレー症候群における糖脂質抗体の展開—フィッシャー症候群関連病態とCa^2＋依存性糖脂質抗体

著者： 千葉厚郎¹ 内堀歩¹ 行田敦子¹

所属機関： ¹杏林大学神経内科

ページ範囲：P.405 - P.417

文献概要

糖脂質抗体研究を軸に，ギラン・バレー症候群の病態解明は進んだ。単独抗原の検討から始まった糖脂質抗体研究は，2つの糖脂質の複合抗原に対する抗体の発見により，その領域をさらに拡大した。最近，ガングリオシドGQ1bとの反応にCa^2＋を必要とする抗体（Ca^2＋依存性GQ1b抗体）が，フィッシャー症候群関連病態で発見された。Ca^2＋はGQ1bのジシアロシル基と相互作用し，抗体はそのCa^2＋が結合した構造を認識していると考えられる。

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