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特集 非アルツハイマー型認知症の病理学
文献概要
前頭側頭葉変性症（FTLD）は，多様な背景病理と遺伝子変異を含む不均一な疾患群である。近年，いくつかの関連遺伝子の発見と，脳内に異常蓄積する蛋白の同定により，FTLDの大部分がFTLD-tau，FTLD-TDP，FTLD-FUSに分類されることが明らかになった。本稿では各群の主要な疾患の組織像について述べ，臨床病型および遺伝子変異との関連について概説する。
参考文献
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