BRAIN and NERVE－神経研究の進歩70巻5号

2018年05月発行

特集 非アルツハイマー型認知症の病理学

神経原線維変化型老年期認知症

著者： 山田正仁¹

所属機関： ¹金沢大学大学院医薬保健学総合研究科脳老化・神経病態学（神経内科学）

ページ範囲：P.533 - P.541

文献概要

神経原線維変化型老年期認知症（SD-NFT）は海馬領域に多量の神経原線維変化（NFT）を有するが老人斑［アミロイドβ蛋白（Aβ）沈着］を欠く高齢者の認知症疾患である。近年，加齢に伴い内側側頭葉にNFTが出現するがAβ沈着を欠く状態を示す病理用語として原発性年齢関連タウオパチー（PART）が提案され，SD-NFTはPART病理の進展による認知症と考えられている。

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