BRAIN and NERVE－神経研究の進歩70巻5号

2018年05月発行

原著

急性期脳梗塞患者に対するアルガトロバン併用抗血小板薬2剤併用療法の安全性

著者： 永金義成¹ 田中瑛次郎¹ 芦田真士¹ 小島雄太¹ 小椋史織¹ 前園恵子¹ 山本康正¹²

所属機関： ¹京都第二赤十字病院脳神経内科 ²京都桂病院脳神経内科

ページ範囲：P.557 - P.562

文献概要

急性期増悪・再発リスクが高い虚血性脳卒中に対して，抗血小板薬2剤併用療法（DAPT）などのより積極的な抗血栓療法が行われているが，一方では出血リスクが増加する。本研究では，ハイリスク例に対してアルガトロバン併用DAPTを行った急性期虚血性脳卒中341例を対象に，退院または入院30日目までの出血性合併症を調査した。症候性頭蓋内出血は認められず，重篤な出血性合併症は1例（0.3％）に認められるのみであった。

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