BRAIN and NERVE－神経研究の進歩70巻7号

2018年07月発行

増大特集 記憶と忘却に関わる脳のしくみ—分子機構から健忘の症候まで

忘却の分子・神経回路メカニズム

著者： 新井美存¹ 石原健¹

所属機関： ¹九州大学大学院理学研究院生物科学部門

ページ範囲：P.689 - P.697

文献概要

動物にとって，記憶の保持時間を適切に制御することは，刻々と変化する環境に適応するために重要である。しかし，能動的に忘却するメカニズムは最近になって研究が緒についたところである。この数年の間に，忘却を制御する分子や忘却を促進する細胞がみつかるなどの成果が得られた。そこで，本稿ではモデル動物を用いた能動的な忘却の分子・神経回路機構に関する最近の知見を紹介する。

参考文献

1)Ebbinghaus H: Memory: A Contribution to Experimental Psychology. Ann Neurosci 20: 155-156, 2013

2)Davis RL, Zhong Y: The biology of forgetting — a perspective. Neuron 95: 490-503, 2017

3)Hardt O, Nader K, Nadel L: Decay happens: the role of active forgetting in memory. Trends Cogn Sci 17: 111-120, 2013

4)Brewin CR: The nature and significance of memory disturbance in posttraumatic stress disorder. Annu Rev Clin Psychol 7: 203-227, 2011

5)Wixted JT: The psychology and neuroscience of forgetting. Annu Rev Psychol 55: 235-269, 2004

6)Dunsmoor JE, Niv Y, Daw N, Phelps EA: Rethinking extinction. Neuron 88: 47-63, 2015

7)Anderson MC, Hanslmayr S: Neural mechanisms of motivated forgetting. Trends Cogn Sci 18: 279-292, 2014

8)Hulbert JC, Henson RN, Anderson MC: Inducing amnesia through systemic suppression. Nat Commun 7: 11003, 2016［doi: 10.1038/ncomms11003］

9)Shuai Y, Lu B, Hu Y, Wang L, Sun K, et al: Forgetting is regulated through Rac activity in Drosophila. Cell. 140: 579-589, 2010

10)Cervantes-Sandoval I, Chakraborty M, MacMullen C, Davis RL: Scribble scaffolds a signalosome for active forgetting. Neuron 90: 1230-1242, 2016

11)Berry JA, Cervantes-Sandoval I, Nicholas EP, Davis RL: Dopamine is required for learning and forgetting in Drosophila. Neuron 74: 530-542, 2012

12)Inoue A, Sawatari E, Hisamoto N, Kitazono T, Teramoto T, et al: Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway. Cell Rep 3: 808-819, 2013

13)Hadziselimovic N, Vukojevic V, Peter F, Milnik A, Fastenrath M, et al: Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex. Cell 156: 1153-1166, 2014

14)Kitazono T, Hara-Kuge S, Matsuda O, Inoue A, Fujiwara M, et al: Multiple signaling pathways coordinately regulate forgetting of olfactory adaptation through control of sensory responses in caenorhabditis elegans. J Neurosci 37: 10240-10251, 2017

15)Lisman J, Yasuda R, Raghavachari S: Mechanisms of CaMKII action in long-term potentiation. Nat Rev Neurosci 13: 169-182, 2012

16)Tsokas P, Hsieh C, Yao Y, Lesburguères E, Wallace EJC, et al: Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice. Elife 5: pii: e14846, 2016［doi: 10.7554/eLife.14846］

17)Genoux D, Haditsch U, Knobloch M, Michalon A, Storm D, et al: Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418: 970-975, 2002

18)Kandel ER: The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol Brain 5: 14, 2002［doi: 10.1186/1756-6606-5-14］

19)Sachser RM, Santana F, Crestani AP, Lunardi P, Pedraza LK, et al: Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca2+ channels, and calcineurin. Sci Rep 6: 22771, 2016［doi: 10.1038/srep22771］

20)Busto GU, Cervantes-Sandoval I, Davis RL: Olfactory learning in drosophila. Physiology (Bethesda) 25: 338-346, 2010

21)Berry JA, Davis RL: Active forgetting of olfactory memories in drosophila. Prog Brain Res 208: 39-62, 2014

22)Heisenberg M: Mushroom body memoir: from maps to models. Nat Rev Neurosci 4: 266-275, 2003

23)Kaun KR, Rothenfluh A: Dopaminergic rules of engagement for memory in Drosophila. Curr Opin Neurobiol 43: 56-62, 2017

24)Himmelreich S, Masuho I, Berry JA, MacMullen C, Skamangas NK, et al: Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila. Cell Rep 21: 2074-2081, 2017

25)White JG, Southgate E, Thomson JN, Brenner S: The structure of the nervous system of the nematode Caenorhabditis elegans. Philos Trans R Soc Lond B Biol Sci 314: 1-340, 1986

26)Kauffman AL, Ashraf JM, Corces-Zimmerman MR, Landis JN, Murphy CT: Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLOS Biol 8: e1000372, 2010［doi: 10.1371/journal.pbio.1000372］

27)Colbert HA, Bargmann CI: Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Neuron 14: 803-812, 1995

28)Sengupta P, Chou JH, Bargmann CI: odr-10 Encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell 84: 899-909, 1996

29)Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, et al: TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nat Immunol 5: 488-494, 2004

30)Kenny EF, O'Neill LA: Signalling adaptors used by Toll-like receptors: an update. Cytokine 43: 342-349, 2008

31)Arellano-Carbajal F, Briseño-Roa L, Couto A, Cheung BH, Labouesse M, et al: Macoilin, a conserved nervous system-specific ER membrane protein that regulates neuronal excitability. PLOS Genet 7: e1001341, 2011［doi: 10.1371/journal.pgen.1001341］

32)Miyara A, Ohta A, Okochi Y, Tsukada Y, Kuhara A, et al: Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans. PLOS Genet 7: e1001384, 2011［doi: 10.1371/journal.pgen.1001384］

33)Weiss JB, Suyama KL, Lee HH, Scott MP: Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation. Cell 107: 387-398, 2001

34)Ishihara T, Iino Y, Mohri A, Mori I, Gengyo-Ando K, et al: HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. Cell 109: 639-649, 2002

35)Shinkai Y, Yamamoto Y, Fujiwara M, Tabata T, Murayama T, et al: Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans. J Neurosci 31: 3007-3015, 2011

36)de Sousa Abreu R, Sanchez-Diaz PC, Vogel C, Burns SC, Ko D, et al: Genomic analyses of Musashi1 downstream targets show a strong association with cancer-related processes. J Biol Chem 284: 12125-12135, 2009

37)Vukojevic V, Gschwind L, Vogler C, Demougin P, De Quervain DJ, et al: A role for α-adducin (ADD-1) in nematode and human memory. EMBO J 31: 1453-1466, 2012