BRAIN and NERVE－神経研究の進歩70巻7号

2018年07月発行

増大特集 記憶と忘却に関わる脳のしくみ—分子機構から健忘の症候まで

学習・記憶の細胞基盤—シナプス・アンサンブルを可視化・操作する技術の創出

著者： 佐藤壮泰¹ 宮本成美¹ 千葉久実¹ 小尾紀翔¹ 林（高木）朗子¹²

所属機関： ¹群馬大学生体調節研究所脳病態制御分野 ²科学技術振興機構さきがけ

ページ範囲：P.713 - P.721

文献概要

記憶はどこに保存されているのか。各種イメージングや光遺伝学・薬理遺伝学の発展に伴い，高い時空間解像度で記憶情報の脳内表現を可視化できるようになったが，記憶の脳内表現とシナプスとの関連は相関関係以上の知見を得ることができなかった。この問題を克服するために，われわれはシナプス光プローブを開発し，記憶を光操作する技術の開発に取り組んできた。記憶を直接操作することで明らかになった知見を概説する。

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