BRAIN and NERVE－神経研究の進歩70巻7号

2018年07月発行

総説

脳構造と脳機能をつなぐプラットフォームとしてのFreeSurfer

著者： 藤原和之¹ 武井雄一¹

所属機関： ¹群馬大学大学院医学系研究科神経精神医学教室

ページ範囲：P.841 - P.848

文献概要

FreeSurferは，頭部MRI画像を処理，分析するためのオープンソースソフトウェアであり，さまざまな脳構造の特徴を簡便に計算できる。本総説では，FreeSurferによって可能なさまざまな脳構造上の特徴評価と神経活動を高い時間空間解像度で評価できる脳磁図について紹介し，マルチモーダル研究におけるFreeSurferのプラットフォームとしての有用性について解説する。

参考文献

1)Fischl B: FreeSurfer. NeuroImage 62: 774-781, 2012

2)Dale A: Source localization and spatial discriminant analysis of event-related potentials: linear approaches. San Diego: University of California at San Diego, 1994

3)Dale AM, Liu AK, Fischl BR, Buckner RL, Belliveau JW, et al: Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activity. Neuron 26: 55-67, 2000

4)Fischl B, Liu A, Dale AM: Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging 20: 70-80, 2001

5)Fischl B, Sereno MI, Dale AM: Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. NeuroImage 9: 195-207, 1999

6)Fischl B, Sereno MI, Tootell RB, Dale AM: High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp 8: 272-284, 1999

7)Fischl B, Salat DH, Busa E, Albert M, Dieterich M, et al: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33: 341-355, 2002

8)Fischl B, Salat DH, van der Kouwe AJ, Makris N, Segonne F, et al: Sequence-independent segmentation of magnetic resonance images. NeuroImage 23 Suppl 1: S69-84, 2004

9)Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, et al: Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med 327: 604-612, 1992

10)Ashburner J, Friston KJ: Voxel-based morphometry--the methods. NeuroImage 11: 805-821, 2000

11)The FIL Methods group: Statistical Parametric Mapping. http://www.fil.ion.ucl.ac.uk/spm/（最終閲覧日2018年7月1日）

12)Wellcome Centre for Integrative Imaging: FMRIB Software Library v5.0. https://fsl.fmrib.ox.ac.uk/fsl/fslwiki（最終閲覧日2018年7月1日）

13)Honea R, Crow TJ, Passingham D, Mackay CE: Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatry 162: 2233-2245, 2005

14)Kuperberg GR, Broome MR, McGuire PK, David AS, Eddy M, et al: Regionally localized thinning of the cerebral cortex in schizophrenia. Arch Gen Psychiatry 60: 878-888, 2003

15)Rimol LM, Nesvag R, Hagler DJ, Jr., Bergmann O, Fennema-Notestine C, et al: Cortical volume, surface area, and thickness in schizophrenia and bipolar disorder. Biol Psychiatry 71: 552-560, 2012

16)Goldman AL, Pezawas L, Mattay VS, Fischl B, Verchinski BA, et al: Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Arch Gen Psychiatry 66: 467-477, 2009

17)Schultz CC, Koch K, Wagner G, Roebel M, Schachtzabel C, et al: Reduced cortical thickness in first episode schizophrenia. Schizophr Res 116: 204-209, 2010

18)Hartberg CB, Sundet K, Rimol LM, Haukvik UK, Lange EH, et al: Subcortical brain volumes relate to neurocognition in schizophrenia and bipolar disorder and healthy controls. Prog Neuropsychopharmacol Biol Psychiatry 35: 1122-1130, 2011

19)van Erp TG, Hibar DP, Rasmussen JM, Glahn DC, Pearlson GD, et al: Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry 21: 547-553, 2016

20)Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, et al: Abnormal asymmetries in subcortical brain volume in schizophrenia. Mol Psychiatry 21: 1460-1466, 2016

21)Vogeley K, Tepest R, Pfeiffer U, Schneider-Axmann T, Maier W, et al: Right frontal hypergyria differentiation in affected and unaffected siblings from families multiply affected with schizophrenia: a morphometric MRI study. Am J Psychiatry 158: 494-496, 2001

22)Harris JM, Yates S, Miller P, Best JJ, Johnstone EC, et al: Gyrification in first-episode schizophrenia: a morphometric study. Biol Psychiatry 55: 141-147, 2004

23)Palaniyappan L, Mallikarjun P, Joseph V, White TP, Liddle PF: Folding of the prefrontal cortex in schizophrenia: regional differences in gyrification. Biol Psychiatry 69: 974-979, 2011

24)Schultz CC, Wagner G, Koch K, Gaser C, Roebel M, et al: The visual cortex in schizophrenia: alterations of gyrification rather than cortical thickness--a combined cortical shape analysis. Brain Struct Funct 218: 51-58, 2013

25)Cao B, Mwangi B, Passos IC, Wu MJ, Keser Z, et al: Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders. Sci Rep 7: 511, 2017

26)Sasabayashi D, Takayanagi Y, Takahashi T, Koike S, Yamasue H, et al: Increased Occipital Gyrification and Development of Psychotic Disorders in Individuals With an At-Risk Mental State: A Multicenter Study. Biol Psychiatry 82: 737-745, 2017

27)三國雅彦, 福田正人, 功刀　浩: 精神疾患診断のための脳形態・機能検査法. 新興医学出版社, 2012

28)高倉公朋, 大久保昭行: MEG脳磁図の基礎と臨床. 朝倉書店, 1994

29)Gramfort A, Luessi M, Larson E, Engemann DA, Strohmeier D, et al: MNE software for processing MEG and EEG data. NeuroImage 86: 446-460, 2014

30)武井雄一, 管　心: 神経生理検査（MEG）, 脳磁図からみる疾患. 笠井清登, 鈴木道雄, 三村　將, 村井俊哉, 福田正人: 精神疾患の脳画像ケースカンファレンス. 中山書店, 東京, 2014, pp120-141, pp335-341,

31)Borgers C, Epstein S, Kopell NJ: Gamma oscillations mediate stimulus competition and attentional selection in a cortical network model. Proc Natl Acad Sci U S A 105: 18023-18028, 2008

32)Hirano Y, Oribe N, Kanba S, Onitsuka T, Nestor PG, et al: Spontaneous Gamma Activity in Schizophrenia. JAMA Psychiatry 72: 813-821, 2015

33)Spencer KM, Salisbury DF, Shenton ME, McCarley RW: Gamma-band auditory steady-state responses are impaired in first episode psychosis. Biol Psychiatry 64: 369-375, 2008

34)Cho RY, Konecky RO, Carter CS: Impairments in frontal cortical gamma synchrony and cognitive control in schizophrenia. Proc Natl Acad Sci U S A 103: 19878-19883, 2006

35)Ohki T, Gunji A, Takei Y, Takahashi H, Kaneko Y, et al: Neural oscillations in the temporal pole for a temporally congruent audio-visual speech detection task. Sci Rep 6: 37973, 2016

36)Khan S, Gramfort A, Shetty NR, Kitzbichler MG, Ganesan S, et al: Local and long-range functional connectivity is reduced in concert in autism spectrum disorders. Proc Natl Acad Sci U S A, 2013

37)Edgar JC, Hunter MA, Huang M, Smith AK, Chen Y, et al: Temporal and frontal cortical thickness associations with M100 auditory activity and attention in healthy controls and individuals with schizophrenia. Schizophr Res 140: 250-257, 2012

38)Edgar JC, Chen YH, Lanza M, Howell B, Chow VY, et al: Cortical thickness as a contributor to abnormal oscillations in schizophrenia? NeuroImage Clin 4: 122-129, 2014

39)Gaetz W, Roberts TP, Singh KD, Muthukumaraswamy SD: Functional and structural correlates of the aging brain: relating visual cortex (V1) gamma band responses to age-related structural change. Hum Brain Mapp 33: 2035-2046, 2012

40)Hunter M, Villarreal G, McHaffie GR, Jimenez B, Smith AK, et al: Lateralized abnormalities in auditory M50 sensory gating and cortical thickness of the superior temporal gyrus in post-traumatic stress disorder: preliminary results. Psychiatry Res 191: 138-144, 2011