BRAIN and NERVE－神経研究の進歩70巻8号

2018年08月発行

特集 レヴィ小体型認知症の新知見

2017年レヴィ小体型認知症臨床診断基準—レム期睡眠行動異常症と指標的バイオマーカー

著者： 藤城弘樹¹

所属機関： ¹かわさき記念病院

ページ範囲：P.869 - P.877

文献概要

2017年のレヴィ小体型認知症の臨床診断基準の改訂では，レム期睡眠行動異常症が中核的特徴に格上げされ，嗅覚低下，過眠，不安，アパシーなどの支持的特徴が追加された。また，診断的バイオマーカーが臨床症状と明確に分離され，診断率の向上とともにバイオマーカーを用いた神経病理学的背景を意識した臨床診断が期待されている。各臨床症状の出現時期を踏まえた臨床経過の把握は，認知症の鑑別診断のうえで重要である。

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