BRAIN and NERVE－神経研究の進歩70巻8号

2018年08月発行

特集 レヴィ小体型認知症の新知見

Cingulate Island Sign

著者： 今林悦子¹

所属機関： ¹エーザイ株式会社

ページ範囲：P.879 - P.888

文献概要

レヴィ小体型認知症（DLB）の新国際診断基準では支持的バイオマーカーの血流・代謝所見に，新たにcingulate island sign（CIS）が取り入れられた。アルツハイマー病では後部帯状回〜楔前部の血流が低下するのに対し，DLBでは後部帯状回の血流は相対的に保持されるという所見で，病理学的には神経原線維変化の進行と逆相関を示すとされている。糖代謝画像での所見とされているが，脳血流SPECT画像でも抽出することが可能であったので，この脳血流SPECT画像におけるCISを中心に述べる。

参考文献

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