BRAIN and NERVE－神経研究の進歩71巻10号

2019年10月発行

特集 認知症と遺伝

アルツハイマー病におけるレアバリアントの役割とその解析意義

著者： 宮下哲典¹ 劉李歆¹ 原範和¹

所属機関： ¹新潟大学脳研究所遺伝子機能解析学分野

ページ範囲：P.1071 - P.1079

文献概要

次世代シーケンサーの登場により，ゲノム・トランスクリプトームなどのオミックス解析方法はこの10年で激変した。膨大なデジタルデータをいかに処理し，解釈するかが原因遺伝子，感受性遺伝子に到達するための重要な鍵となった。認知症のおよそ6〜7割を占めるアルツハイマー病のバリアント探索はコモンからレア，そしてプライベートなバリアントへとシフトし，新たな展開を迎えている。本論ではその最新情報の一端を紹介する。

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