BRAIN and NERVE－神経研究の進歩72巻10号

2020年10月発行

特集 COVID-19—脳神経内科医が診るための最新知識

—COVID-19神経合併症（2）—脳血管障害と血管炎症候群

著者： 八木田佳樹¹

所属機関： ¹川崎医科大学脳卒中医学

ページ範囲：P.1039 - P.1043

文献概要

新型コロナウイルス感染症（COVID-19）蔓延に伴い，脳血管障害や血管炎関連疾患の合併が報告されるようになった。SARS-CoV-2が血管内皮細胞に発現するアンジオテンシン変換酵素阻害薬2（ACE2）を介して，血管内皮細胞に感染，炎症を惹起することがその機序として推定されている。またCOVID-19重症例に合併することが多く，全身状態悪化に伴うサイトカインストームや血栓形成傾向も影響していると考えられる。COVID-19に関連する脳血管障害や血管炎の病態を明らかにし，最善の治療法を確立していくことが望まれる。

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