BRAIN and NERVE－神経研究の進歩72巻10号

2020年10月発行

症例報告

髄膜腫再発が疑われた膠芽腫の1例

著者： 小林裕介¹² 三島一彦¹ 安達淳一¹ 鈴木智成¹ 佐々木惇³ 西川亮¹

所属機関： ¹埼玉医科大学国際医療センター脳脊髄腫瘍科 ²昭和大学医学部脳神経外科 ³埼玉医科大学医学部病理学

ページ範囲：P.1105 - P.1111

文献概要

髄膜腫と神経膠腫が同部位に発生することは非常に稀である。今回われわれは，髄膜腫摘出後に再発が疑われ腫瘍摘出を行ったところ膠芽腫であった1例を経験した。症例は67歳女性，左前頭部髄膜腫に対して摘出術が行われ，fibrous meningiomaと診断された。術後2年11カ月目に摘出部に腫瘍を認め再発を疑い摘出術を行った。悪性髄膜腫が疑われたが，病理組織診断は膠芽腫であった。IDHはwild type，TERT promoterのmutationを認め，de novoに発生した膠芽腫と診断した。

参考文献

1)The Committee of Brain Tumor Registry of Japan: Brain tumor registry of Japan (2005-2008). Neurologia medico-chirurgica 57(Suppl 1): 9-102, 2017

2)Mitsos AP, Konstantinou EA, Fotis TG, Lafazanos SA, Kontogeorgos G, et al: Sphenoid wing meningioma and glioblastoma multiforme in collision - case report and review of the literature. Neurol Neurochir Pol 43: 479-483, 2009

3)Ohba S, Shimizu K, Shibao S, Miwa T, Nakagawa T, et al: A glioblastoma arising from the attached region where a meningioma had been totally removed. Neuropathology 31: 606-611, 2011

4)Pereira EA, Dabbous B, Qureshi HU, Ansorge O, Bojanic S: Rapid development of glioblastoma at the site of atypical meningioma resection. Br J Neurosurg 24: 471-473, 2010

5)Raco A, Cervoni L, Salvati M: Two distinct intracranial tumors of different cell types in a single patient. Case report and review of the literature. Neurosurg Rev 17: 305-308, 1994

6)Sahuc P, Joubert C, Nguyen A-T, Fouet B, Wybrecht D, et al: Glioblastoma secondary to meningioma: a case report and literature review. World Neurosurg 98: 881. e9-881. e13, 2017［doi: 10.1016/j.wneu.2016.11.025］

7)Spallone A, Santoro A, Palatinsky E, Giunta F: Intracranial meningiomas associated with glial tumours: a review based on 54 selected literature cases from the literature and 3 additional personal cases. Acta Neurochir (Wien) 110: 133-139, 1991

8)Kruse F Jr: Meningeal tumors with extracranial metastasis: a clinicopathologic report of 2 cases. Neurology 10: 197-201, 1960

9)LeMay DR, Bucci MN, Farhat SM: Malignant transformation of recurrent meningioma with pulmonary metastases. Surg Neurol 31: 365-368, 1989

10)Salvati M, D'Elia A, Melone GA, Brogna C, Frati A, et al: Radio-induced gliomas; 20-year experience and critical review of the pathology. J Neurooncol 89: 169-177, 2008

11)Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, et al: IDH1 and IDH2 mutations in gliomas. N Engl J Med 360: 765-773, 2009

12)Zhou B, Liu W: Post-traumatic glioma: report of one case and review of the literature. Int J Med Sci 7: 248-250, 2010

13)Munch TN, Gørtz S, Wohlfahrt J, Melbye M: The long-term risk of malignant astrocytic tumors after structural brain injury: a nationwide cohort study. Neuro Oncol 17: 718-24, 2015

14)Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, et al: TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A 110: 6021-6026, 2013

15)Sahm F, Schrimpf D, Olar A, Koelsche C, Reuss D, et al: TERT Promoter mutations and risk of recurrence in meningioma. J Natl Cancer Inst 108: djv377, 2016［doi: 10.1093/jnci/djv377］

16)Phi JH, Park AK, Lee S, Choi SA, Baek I-P, et al: Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomas. Acta Neuropathol 135: 939-953, 2018