BRAIN and NERVE－神経研究の進歩72巻11号

2020年11月発行

増大特集 脳の発振現象—基礎から臨床へ

細胞発振から集団発振へのモーダルシフトにおけるCl^--GABAシステムの関わり

著者： 福田敦夫¹²

所属機関： ¹浜松医科大学医学部神経生理学講座 ²浜松医科大学光尖端医学教育研究センター先進機器共用推進部

ページ範囲：P.1127 - P.1134

文献概要

GABA_A受容体作用はCl^-濃度勾配に依存し，成熟脳ではCl^-流入による過分極・抑制であるが，未成熟な脳では脱分極（Cl^-流出）である。Cl^-ホメオダイナミクスは抑制と興奮を切り替えて，細胞および細胞集団の発振現象におけるモーダルシフトを起こす。このGABA作用のモーダルシフトは，正常な脳発達に必要な一方で，成熟脳で逆説的に誘導されることもあり，モーダルシフトの障害は，種々の神経発達障害の病因・病態となり得る。

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