文献詳細
増大特集 神経疾患の診断における落とし穴—誤診を避けるために
文献概要
日本における高齢者人口の増加とともに認知症患者は増加の一途をたどっており,今後もその傾向は続くものと見られている。また,65歳未満で発症する若年性認知症(早期発症型認知症)についても認知症疾患全体の中では発症率が少ないものの,本人の就労困難や介護負担など社会的問題として捉えられており,新オレンジプランの施策においても主要項目の1つとして,今後の取組みの重要性が提言されている。認知症には多様な疾患が存在し,正確な診断が行われないことにより,患者の予後が悪化する可能性があり,十分に注意を払って正確な診断を行うことが必要である。また,発症初期の段階で,確定診断に到達できなくても,その後に確定診断できることもあるため,経時的な患者の病状や症候の解釈,検査データを理解して診断を進めていくことが大切である。
参考文献
1)日本神経学会(監修), 「認知症疾患診療ガイドライン」作成委員会(編): 認知症疾患診療ガイドライン2017. 医学書院, 東京, 2017
2)Mathew R, Bak TH, Hodges JR: Diagnostic criteria for corticobasal syndrome: a comparative study. J Neurol Neurosurg Psychiatry 83: 405-410, 2012
3)Armstrong MJ, Litvan I, Lang AE, Bak TH, Bhatia KP, et al: Criteria for the diagnosis of corticobasal degeneration. Neurology 80: 496-503, 2013
4)Josephs KA, Whitwell JL, Boeve BF, Knopman DS, Petersen RC, et al: Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease. Mov Disord 25: 1246-1252, 2010
5)Sakae N, Josephs KA, Litvan I, Murray ME, Duara R, et al: Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome. Alzheimers Dement 15: 1218-1228, 2019
C PiB-PET studies in three clinical variants of primary progressive aphasia and Alzheimer's disease. Amyloid 21: 238-245, 2014
7)Kasahara H, Ikeda M, Nagashima K, Fujita Y, Makioka K, et al: Deep White Matter Lesions Are Associated with Early Recognition of Dementia in Alzheimer's Disease. J Alzheimers Dis 68: 797-808, 2019
8)Lang AE, Riley DE, Bergeron C: Cortico-basal Ganglionic Degeneration. Calne MD, Donald B (eds): Neurodegenerative Diseases. Saunders, Philadelphia, 1994, pp877-894
9)Boeve BF, Lang AE, Litvan I: Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia. Ann Neurol 54: 15-19, 2003
10)Shelley BP, Hodges JR, Kipps CM, Xuereb JH, Bak TH: Is the pathology of corticobasal syndrome predictable in life? Mov Disord 24: 1593-1599, 2009
11)Galton CJ, Patterson K, Xuereb JH, Hodges JR: Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases. Brain 123: 484-498, 2000
12)Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, et al: Classification of primary progressive aphasia and its variants. Neurology 76: 1006-1014, 2011
13)Crutch SJ, Lehmann M, Schott JM, Rabinovici GD, Rossor MN, et al: Posterior cortical atrophy. Lancet Neurol 11: 170-178, 2011
14)Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, et al: The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain 138: 2732-2749, 2015
15)Rohrer JD, Rossor MN, Warren JD: Alzheimer's pathology in primary progressive aphasia. Neurobiol Aging 33: 744-752, 2012
16)McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, et al: The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7: 263-269, 2011
17)日本精神神経学会(日本語版用語監修), 高橋三郎, 大野 裕(監訳), 染矢俊幸, 神庭重信, 尾崎紀夫, 三村 將, 村井俊哉(訳): DSM-5精神疾患の診断・統計マニュアル. 医学書院, 東京, 2014
18)Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, et al: Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol 13: 614-629, 2014
19)Mendez MF, Moheb N, Desarzant RE, Teng EH: The Progressive Acalculia Presentation of Parietal Variant Alzheimer's Disease. J Alzheimers Dis 63: 941-948, 2018
20)Lee SE, Rabinovici GD, Mayo MC, Wilson SM, Seeley WW, et al: Clinicopathological correlations in corticobasal degeneration. Ann Neurol 70: 327-340, 2011
21)Saito Y, Nakahara K, Yamanouchi H, Murayama S: Severe involvement of ambient gyrus in dementia with grains. J Neuropathol Exp Neurol 61: 789-796, 2002
22)Yamada M: Senile dementia of the neurofibrillary tangle type (tangle-only dementia): neuropathological criteria and clinical guidelines for diagnosis. Neuropathology 23: 311-317, 2003
23)Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, et al: Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol 128: 755-766, 2014
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