BRAIN and NERVE－神経研究の進歩73巻11号

2021年11月発行

総説

ポリコーム群蛋白質を介した脳形成の地図をつくるメカニズム

著者： 山田夏実¹ 椙下紘貴¹

所属機関： ¹東京大学薬学部分子生物学教室

ページ範囲：P.1261 - P.1266

文献概要

脳が複雑な機能を獲得できるのは，神経幹細胞が遺伝子の転写を正しく制御することで，脳の領域ごとに異なる性質のニューロンやグリア細胞を産生しているからである。モルフォジェンやポリコーム複合体は，領域特異的な遺伝子の転写制御によって，発生初期に脳の地図形成に貢献している。われわれはポリコーム群蛋白質のRING1Bがモルフォジェンの発現を領域特異的に抑制することで脳の背腹軸形成を促すことを明らかにした。

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