BRAIN and NERVE－神経研究の進歩73巻7号

2021年07月発行

特集 グリアと神経—相補的な制御系として

ストレスを介したミクログリア活性化と精神疾患—双方向性研究アプローチ

著者： 榎本真悟¹² 加藤隆弘²

所属機関： ¹自衛隊福岡病院精神科 ²九州大学大学院医学研究院精神病態医学

ページ範囲：P.795 - P.802

文献概要

ストレスはうつ病や心的外傷後ストレス障害（PTSD）の誘因であり，それらの疾患の病態にミクログリアの過剰活性化や機能不全が関与していることを示唆する知見が現在集まってきている。本論では，PTSDに特徴的な恐怖記憶制御不全を示す動物モデルでのミクログリアの機能変化と，ミクログリアに焦点を絞ったヒトを対象とするうつ病およびPTSD研究の知見を紹介する。ヒトとモデル動物での双方向性研究が，病態解明と治療法開発のために必要である。

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