BRAIN and NERVE－神経研究の進歩73巻7号

2021年07月発行

総説

成体海馬の新生ニューロンが睡眠中に記憶を固定化する

著者： 菅谷佑樹¹ 坂口昌徳²

所属機関： ¹東京大学大学院医学系研究科神経生理学分野 ²筑波大学国際統合睡眠医科学研究機構

ページ範囲：P.813 - P.817

文献概要

霊長類の脳の海馬では，性成熟が完了した後でも例外的にニューロンが新生する。これらの新生ニューロンがどのように既存のニューロンと機能的な神経回路をつくるかは明らかでない。筆者らは世界で初めてこれらの新生ニューロンがレム睡眠中の記憶固定化に必須の役割を果たすことを明らかにした。このメカニズムを解明し新生ニューロンが機能的な回路を形成する過程を明らかにすることで，中枢神経の再生医療の発展に貢献したい。

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