BRAIN and NERVE－神経研究の進歩73巻8号

2021年08月発行

特集 脳腸相関—脳-身体の双方向性制御

小さな運び屋エクソソームを介した脳腸相関

著者： 杉浦圭¹² 志村日向子¹ 星野歩子¹

所属機関： ¹東京工業大学生命理工学院 ²東京大学大学院薬学系研究科

ページ範囲：P.879 - P.887

文献概要

細胞から放出されるエクソソームは多様な細胞情報を遠隔臓器に伝えることができる。近年脳の監視網である血液脳関門をエクソソームが通り抜けることが報告され，がんの脳転移や精神神経疾患との関わりが注目を集めている。また，腸内細菌が放出しているエクソソーム（BEVs）も神経変性疾患への影響がある可能性が示唆された。本論ではBEVsを含む，エクソソームと精神神経疾患との関係性を最新の知見を含めて議論する。

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