BRAIN and NERVE－神経研究の進歩73巻9号

2021年09月発行

特集 脳卒中治療に必要な基礎知識

脳浮腫時における水分子の循環とアクアポリン4

著者： 石川智愛¹ 安井正人¹

所属機関： ¹慶應義塾大学医学部薬理学

ページ範囲：P.983 - P.989

文献概要

脳浮腫は脳卒中や外傷性脳損傷による死亡の主要な原因となっているが，その治療法はいまだ限られており，根治療法は存在しない。脳内の主要な水チャネルであるアクアポリン4（AQP4）は脳水循環や浮腫の制御に重要な役割を果たすと考えられている。そのため，AQP4の発現や機能を制御することで浮腫を制御する試みが進んでいる。AQP4の特性や機能の詳細な理解により，AQP4をターゲットとした浮腫治療システムの構築が期待される。

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