BRAIN and NERVE－神経研究の進歩73巻9号

2021年09月発行

特集 脳卒中治療に必要な基礎知識

ラクナ梗塞の再考—フィッシャーの呪縛を超えて

著者： 小野寺理¹ 上村昌寛¹ 安藤昭一朗¹ 林秀樹¹ 金澤雅人¹

所属機関： ¹新潟大学腦研究所臨床神経科学部門脳神経内科

ページ範囲：P.991 - P.998

文献概要

ラクナ梗塞は，穿通枝領域の小梗塞で，高血圧によるリポヒアリノーシスを特徴としてフィッシャーにより提唱された。降圧薬の普及した現在は，主に，アテロームによる機序と，アテロームがない機序による。後者は，深部白質障害を合併する。また白質障害を伴うラクナ梗塞群では，細胞外基質などに関与するリスク遺伝子群が見出された。これらの事実は，白質障害を伴うラクナ梗塞に，高血圧以外の特殊性が存在することを示唆する。

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