BRAIN and NERVE－神経研究の進歩74巻11号

2022年11月発行

総説

レム睡眠の開始機構—睡眠周期の生成に関するドーパミンと扁桃体の新たな役割

著者： 長谷川恵美¹²

所属機関： ¹筑波大学医学医療系 ²筑波大学国際統合睡眠医科学研究機構

ページ範囲：P.1303 - P.1308

文献概要

睡眠はレム睡眠とノンレム睡眠を交互に繰り返すという特徴的なパターンを示すが，このような睡眠サイクルがどのように作られているかは不明であった。筆者らは扁桃体におけるノンレム睡眠中の一時的なドーパミン濃度の上昇が，レム睡眠の開始に不可欠であることを見出した。さらに，睡眠障害・ナルコレプシー症状の1つであるレム睡眠関連症状とされるカタプレキシー発作についても同様のシステムを使っていることがわかった。

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