文献詳細
特集 温度を感じる脳と身体の科学
文献概要
人間を含めた哺乳動物の体温調節システムは単に深部体温を一定に保つだけでなく,環境中に存在する暑熱,寒冷,病原体,天敵,飢餓などのさまざまなストレッサーを受けた際には,生命を守るために必要に応じて体温を大きく変動させる。最近の研究から,こうした環境ストレスに対する体温調節反応に関わる脳の神経回路が明らかとなってきた。本論では,環境ストレスに応じた体温調節の中枢神経ネットワークに関する最新知見を紹介する。
参考文献
1)Nakamura K: Central circuitries for body temperature regulation and fever. Am J Physiol Regul Integr Comp Physiol 301: R1207-R1228, 2011
2)Morrison SF, Nakamura K: Central mechanisms for thermoregulation. Annu Rev Physiol 81: 285-308, 2019
3)Nakamura K, Matsumura K, Hübschle T, Nakamura Y, Hioki H, et al: Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci 24: 5370-5380, 2004
4)Nakamura K, Nakamura Y, Kataoka N: A hypothalamomedullary network for physiological responses to environmental stresses. Nat Rev Neurosci 23: 35-52, 2022
5)Kataoka N, Hioki H, Kaneko T, Nakamura K: Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia. Cell Metab 20: 346-358, 2014
6)Nakayama T, Eisenman JS, Hardy JD: Single unit activity of anterior hypothalamus during local heating. Science 134: 560-561, 1961
7)McAllen RM, Tanaka M, Ootsuka Y, McKinley MJ: Multiple thermoregulatory effectors with independent central controls. Eur J Appl Physiol 109: 27-33, 2010
8)Craig AD: How do you feel? interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 3: 655-666, 2002
9)Nakamura K, Morrison SF: A thermosensory pathway that controls body temperature. Nat Neurosci 11: 62-71, 2008
10)Yahiro T, Kataoka N, Nakamura Y, Nakamura K: The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation. Sci Rep 7: 5031, 2017[doi: 10.1038/s41598-017-05327-8]
11)Nakamura K, Morrison SF: A thermosensory pathway mediating heat-defense responses. Proc Natl Acad Sci U S A 107: 8848-8853, 2010
12)Geerling JC, Kim M, Mahoney CE, Abbott SBG, Agostinelli LJ, et al: Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol 310: R41-R54, 2016
13)Cintron-Colon R, Johnson CW, Montenegro-Burke JR, Guijas C, Faulhaber L, et al: Activation of kappa opioid receptor regulates the hypothermic response to calorie restriction and limits body weight loss. Curr Biol 29: 4291-4299, 2019
14)Yang WZ, Du X, Zhang W, Gao C, Xie H, et al: Parabrachial neuron types categorically encode thermoregulation variables during heat defense. Sci Adv 6: eabb9414, 2020[doi: 10.1126/sciadv.abb9414]
15)Chen XM, Hosono T, Yoda T, Fukuda Y, Kanosue K: Efferent projection from the preoptic area for the control of non-shivering thermogenesis in rats. J Physiol 512: 883-892, 1998
16)Morrison SF, Sved AF, Passerin AM: GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. Am J Physiol 276: R290-R297, 1999
17)Zaretskaia MV, Zaretsky DV, Shekhar A, DiMicco JA: Chemical stimulation of the dorsomedial hypothalamus evokes non-shivering thermogenesis in anesthetized rats. Brain Res 928: 113-125, 2002
18)Nakamura K, Matsumura K, Kaneko T, Kobayashi S, Katoh H, et al: The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J Neurosci 22: 4600-4610, 2002
19)Nakamura Y, Nakamura K, Matsumura K, Kobayashi S, Kaneko T, et al: Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. Eur J Neurosci 22: 3137-3146, 2005
20)Tan CL, Cooke EK, Leib DE, Lin YC, Daly GE, et al: Warm-sensitive neurons that control body temperature. Cell 167: 47-59, 2016
21)Tanaka M, McKinley MJ, McAllen RM: Preoptic-raphé connections for thermoregulatory vasomotor control. J Neurosci 31: 5078-5088, 2011
22)da Conceição EPS, Morrison SF, Cano G, Chiavetta P, Tupone D: Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat. Sci Rep 10: 18072, 2020[doi: 10.1038/s41598-020-74272-w]
23)Piñol RA, Mogul AS, Hadley CK, Saha A, Li C, et al: Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways. Cell Metab 33: 1389-1403, 2021
24)Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, et al: Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 21: 2669-2677, 2001
25)Nakamura K, Kaneko T, Yamashita Y, Hasegawa H, Katoh H, et al: Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neurosci Lett 260: 117-120, 1999
26)Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, et al: EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci 10: 1131-1133, 2007
27)Machado NLS, Bandaru SS, Abbott SBG, Saper CB: EP3R-expressing glutamatergic preoptic neurons mediate inflammatory fever. J Neurosci 40: 2573-2588, 2020
28)Oka T: Psychogenic fever: how psychological stress affects body temperature in the clinical population. Temperature 2: 368-378, 2015
29)Ootsuka Y, Blessing WW, Nalivaiko E: Selective blockade of 5-HT2A receptors attenuates the increased temperature response in brown adipose tissue to restraint stress in rats. Stress 11: 125-133, 2008
30)Lkhagvasuren B, Nakamura Y, Oka T, Sudo N, Nakamura K: Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region. Eur J Neurosci 34: 1442-1452, 2011
31)Ootsuka Y, McAllen RM: Interactive drives from two brain stem premotor nuclei are essential to support rat tail sympathetic activity. Am J Physiol Regul Integr Comp Physiol 289: R1107-R1115, 2005
32)Horiuchi J, McAllen RM, Allen AM, Killinger S, Fontes MAP, et al: Descending vasomotor pathways from the dorsomedial hypothalamic nucleus: role of medullary raphe and RVLM. Am J Physiol Regul Integr Comp Physiol 287: R824-R832, 2004
33)Kataoka N, Shima Y, Nakajima K, Nakamura K: A central master driver of psychosocial stress responses in the rat. Science 367: 1105-1112, 2020
signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52: 948-956, 2003
35)Stanley BG, Leibowitz SF: Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc Natl Acad Sci U S A 82: 3940-3943, 1985
36)Egawa M, Yoshimatsu H, Bray GA: Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats. Am J Physiol 260: R328-R334, 1991
37)Nakamura Y, Yanagawa Y, Morrison SF, Nakamura K: Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication. Cell Metab 25: 322-334, 2017
38)Moore JD, Kleinfeld D, Wang F: How the brainstem controls orofacial behaviors comprised of rhythmic actions. Trends Neurosci 37: 370-380, 2014
39)Nakamura K, Nakamura Y: Hunger and satiety signaling: modeling two hypothalamomedullary pathways for energy homeostasis. Bioessays 40: e1700252, 2018[doi: 10.1002/bies.201700252]
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