BRAIN and NERVE－神経研究の進歩74巻3号

2022年03月発行

特集 中枢性自律神経障害update

タウオパチーにおける自律神経障害の捉え方

著者： 古賀俊輔¹ 饗場郁子²

所属機関： ¹メイヨークリニック神経科学部門 ²国立病院機構東名古屋病院脳神経内科

ページ範囲：P.257 - P.262

文献概要

進行性核上性麻痺（PSP）と大脳皮質基底核変性症（CBD）は非定型パーキンソン症状を呈するタウオパチーである。PSPでは排尿障害や便秘は頻繁に認められ，生命予後に影響することが明らかになった。一方，起立性低血圧はPSPでは稀で，多系統萎縮症やレビー小体病との鑑別に有用である。CBDでも排尿障害が頻繁に見られ，尿失禁はCBDの臨床病型であるPSP症候群の診断基準に含まれているものの，さらなる検証が必要である。

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