BRAIN and NERVE－神経研究の進歩75巻11号

2023年11月発行

特集 アロスタシス—ホメオスタシスを超えて

慢性疼痛とアロスタシス—グリア細胞の役割

著者： 津田誠¹

所属機関： ¹九州大学大学院薬学研究院薬理学分野

ページ範囲：P.1225 - P.1229

文献概要

体性感覚神経系の傷害や疾患によって神経障害性疼痛という慢性疼痛が発症する。最近，この慢性疼痛モデルマウスを用いた研究から，神経損傷後に脊髄で出現するCD11c陽性ミクログリアが疼痛症状の寛解に重要な細胞として特定された。本論では，神経損傷後のミクログリアの状態変遷と，CD11c陽性ミクログリアによる神経障害性疼痛に対するアロスタティックな制御機構について概説する。

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