BRAIN and NERVE－神経研究の進歩75巻11号

2023年11月発行

特集 アロスタシス—ホメオスタシスを超えて

内受容感覚とアロスタシスからみた精神疾患

著者： 是木明宏¹ 寺澤悠理²

所属機関： ¹国立病院機構下総精神医療センター精神科 ²慶應義塾大学文学部心理学専攻

ページ範囲：P.1251 - P.1257

文献概要

古典的なアロスタシスの概念はストレスに対する動的な適応能として提唱され，その機能への過剰な負荷は適応反応症として現れ，さらにはさまざまな精神疾患を引き起こし得る。また近年のアロスタシスの概念は生理的変化のみならず行動的変化をも説明し，さらに内受容感覚は感情のみならず自己感との関係性が近年注目されているが，このような近年の概念拡張およびその異常が統合失調症の症状理解に役立つ可能性がある。

参考文献

1）Sherrington CS: The Integrative Action of the Nervous System. Yale University Press, New Haven, 1906

2）Sterling P: Allostasis: a model of predictive regulation. Physiol Behav 106: 5-15, 2012

3）Fava GA, McEwen BS, Guidi J, Gostoli S, Offidani E, et al: Clinical characterization of allostatic overload. Psychoneuroendocrinology 108: 94-101, 2019

4）Corcoran AW, Hohwy J: Allostasis, Interoception, and the Free Energy Principle: Feeling Our Way Forward. Tsakiris M, De Preester H(eds): The Interoceptive Mind: from Homeostasis to Awareness. Oxford University Press, Oxford, 2018, pp272-292

5）Cannon WB: Adrenal Secretion in Strong Emotions and Pain. Bodily changes in pain, hunger, fear, and rage. Harper＆Row, New York, 1929, pp52-65

6）Selye H: The Story of the Adaption Syndrome. ACTA INC., Montreal, 1952

7）Hurrell JJ Jr, McLaney MA: Exposure to job stress: a new psychometric instrument. Scand J Work Environ Health 14 Suppl 1: 27-28, 1988

8）Shimomitsu T, Haratani T, Nakamura K, Kawakami N, Hayashi T, et al: Final Development of the Brief Job Stress Questionnaire Mainly Used for Assessment of the Individuals. Kato M: The Ministry of Labor Sponsored Grant for the Prevention of Work-related Illness, FY 1999 report. Tokyo Medical University, Tokyo, 2000, pp126-164

9）D'Alessio L, Korman GP, Sarudiansky M, Guelman LR, Scévola L, et al: Reducing allostatic load in depression and anxiety disorders: physical activity and yoga practice as add-on therapies. Front Psychiatry 11: 501, 2020［doi: 10.3389/fpsyt.2020.00501］

10）Christensen DS, Zachariae R, Amidi A, Wu LM: Sleep and allostatic load: a systematic review and meta-analysis. Sleep Med Rev 64: 101650, 2022［doi: 10.1016/j.smrv.2022.101650］

11）Sanada K, Montero-Marin J, Barceló-Soler A, Ikuse D, Ota M, et al: Effects of mindfulness-based interventions on biomarkers and low-grade inflammation in patients with psychiatric disorders: a meta-analytic teview. Int J Mol Sci 21: 2484, 2020［doi: 10.3390/ijms21072484］

12）Guidi J, Lucente M, Sonino N, Fava GA: Allostatic load and its impact on health: a systematic review. Psychother Psychosom 90: 11-27, 2021

13）Juster RP, Sasseville M, Giguère CÉ, Consortium S, Lupien SJ: Elevated allostatic load in individuals presenting at psychiatric emergency services. J Psychosom Res 115: 101-109, 2018

14）Eberle DJ, Maercker A: Preoccupation as psychopathological process and symptom in adjustment disorder: a scoping review. Clin Psychol Psychother 29: 455-468, 2022

15）Strain JJ: The psychobiology of stress, depression, adjustment disorders and resilience. World J Biol Psychiatry 19(sup1): S14-S20, 2018

16）Bärtl C, Henze GI, Giglberger M, Peter HL, Konzok J, et al: Higher allostatic load in work-related burnout: The Regensburg Burnout Project. Psychoneuroendocrinology 143: 105853, 2022［doi: 10.1016/j.psyneuen.2022.105853］

17）Konlan KD, Asampong E, Dako-Gyeke P, Glozah FN: Burnout and allostatic load among health workers engaged in human resourced-constrained hospitals in Accra, Ghana. BMC Health Serv Res 22: 1163, 2022［doi: 10.1186/s12913-022-08539-5］

18）Malhi GS, Mann JJ: Depression. Lancet 392: 2299-2312, 2018

19）Karatsoreos IN, McEwen BS: Psychobiological allostasis: resistance, resilience and vulnerability. Trends Cogn Sci 15: 576-584, 2011

20）Khalsa SS, Adolphs R, Cameron OG, Critchley HD, Davenport PW, et al; Interoception Summit 2016 participants: Interoception and mental health: a roadmap. Biol Psychiatry Cogn Neurosci Neuroimaging 3: 501-513, 2018

21）Quadt L, Esposito G, Critchley HD, Garfinkel SN: Brain-body interactions underlying the association of loneliness with mental and physical health. Neurosci Biobehav Rev 116: 283-300, 2020

22）Yao B, Thakkar K: Interoception abnormalities in schizophrenia: a review of preliminary evidence and an integration with Bayesian accounts of psychosis. Neurosci Biobehav Rev 132: 757-773, 2022

23）Gallagher I I: Philosophical conceptions of the self: implications for cognitive science. Trends Cogn Sci 4: 14-21, 2000

24）Braun N, Debener S, Spychala N, Bongartz E, Sörös P, et al: The senses of agency and ownership: a review. Front Psychol 9: 535, 2018［doi: 10.3389/fpsyg.2018.00535］

25）Quigley KS, Kanoski S, Grill WM, Barrett LF, Tsakiris M: Functions of interoception: from energy regulation to experience of the self. Trends Neurosci 44: 29-38, 2021

26）Koreki A, Goeta D, Ricciardi L, Eilon T, Chen J, et al: The relationship between interoception and agency and its modulation by heartbeats: an exploratory study. Sci Rep 12: 13624, 2022［doi: 10.1038/s41598-022-16569-6］

27）Suzuki K, Garfinkel SN, Critchley HD, Seth AK: Multisensory integration across exteroceptive and interoceptive domains modulates self-experience in the rubber-hand illusion. Neuropsychologia 51: 2909-2917, 2013

28）Heydrich L, Aspell JE, Marillier G, Lavanchy T, Herbelin B, et al: Cardio-visual full body illusion alters bodily self-consciousness and tactile processing in somatosensory cortex. Sci Rep 8: 9230, 2018［doi: 10.1038/s41598-018-27698-2］

29）Koreki A, Maeda T, Fukushima H, Umeda S, Takahata K, et al: Behavioral evidence of delayed prediction signals during agency attribution in patients with schizophrenia. Psychiatry Res 230: 78-83, 2015

30）Koreki A, Maeda T, Okimura T, Terasawa Y, Kikuchi T, et al: Dysconnectivity of the agency network in schizophrenia: a functional magnetic resonance imaging study. Front Psychiatry 10: 171, 2019［doi: 10.3389/fpsyt.2019.00171］

31）Conrad K: Die beginnende Schizophrenie. Thieme Verlag, Stuttgart, 1958

32）Kapur S: Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 160: 13-23, 2003

33）古茶大樹, 前田貴記, 鹿島晴雄: 統合失調症の仮性幻覚について. Schizophrenia Frontier 10: 24-28, 2009

34）中安信夫: 体験を聴く・症候を読む・病態を解く—精神症候学の方法についての覚書. 星和書店, 東京, 2008

35）Ceunen E, Vlaeyen JW, Van Diest I: On the origin of interoception. Front Psychol 7: 743, 2016［doi: 10.3389/fpsyg.2016.00743］

36）Critchley HD, Garfinkel SN: Interoception and emotion. Curr Opin Psychol 17: 7-14, 2017

37）Koreki A, Funayama M, Terasawa Y, Onaya M, Mimura M: Aberrant interoceptive accuracy in patients with schizophrenia performing a heartbeat counting task. Schizophr Bull Open 2: sgaa067, 2021［doi: 10.1093/schizbullopen/sgaa067］

38）García-Portilla MP, García-Álvarez L, González-Blanco L, Dal Santo F, Bobes-Bascarán T, et al: Real-world functioning in patients with schizophrenia: beyond negative and cognitive symptoms. Front Psychiatry 12: 700747, 2021［doi: 10.3389/fpsyt.2021.700747］

39）Galderisi S, Kaiser S: The pathophysiology of negative symptoms of schizophrenia: main hypotheses and open challenges. Br J Psychiatry 223: 298-300, 2023

40）Clamor A, Lincoln TM, Thayer JF, Koenig J: Resting vagal activity in schizophrenia: meta-analysis of heart rate variability as a potential endophenotype. Br J Psychiatry 208: 9-16, 2016

41）Nagashima T, Inoue M, Kitamura S, Kiuchi K, Kosaka J, et al: Brain structural changes and neuropsychological impairments in male polydipsic schizophrenia. BMC Psychiatry 12: 210, 2012［doi: 10.1186/1471-244X-12-210］

42）Seth AK, Tsakiris M: Being a beast machine: the somatic basis of selfhood. Trends Cogn Sci 22: 969-981, 2018