BRAIN and NERVE－神経研究の進歩75巻6号

2023年06月発行

特集 Antibody Update 2023　Part1 中枢編

神経系自己抗体産生のメカニズムとその病的意義

著者： 松尾欣哉¹ 竹下幸男¹²³

所属機関： ¹山口大学大学院医学系研究科臨床神経学講座 ²山口大学医学部血液脳神経関門先進病態創薬研究講座 ³山口大学医学部神経・筋難病治療学講座

ページ範囲：P.687 - P.693

文献概要

自己抗体の産生メカニズムは疾患ごとに異なるが，多くの自己抗体産生に共通する機序として，免疫寛容システムの機能不全が注目されている。産生された自己抗体が中枢神経内へ到達するためには血液脳関門をはじめとした種々の生体関門を通過しなければならない。さらに自己抗体の標的抗原への直接的な作用は抗体ごとに大きく異なっている。自己抗体産生とその作用機序の解明はより根本的かつ効果的な治療法の開発につながる。

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