ログイン
ランキング
お知らせ
ログイン
文献詳細
特集 Antibody Update 2023 Part1 中枢編
文献概要
傍腫瘍性神経症候群は，悪性腫瘍に対する免疫寛容の破綻が，共通抗原を有する神経組織の攻撃要因になるために生じると考えられ，多様な神経症候群を呈する。一般に急性経過で高度の神経症候を生じ，腫瘍の発見は遅れることが多い。病型，腫瘍，自己抗体の組合せに一定の特徴があり，抗体種によって病態への関与，検出方法，治療法や治療反応性が異なる。抗体による腫瘍合併頻度を踏まえて分類される。
参考文献
1)Graus F, Vogrig A, Muñiz-Castrillo S, Antoine JCG, Desestret V, et al: Updated diagnostic criteria for paraneoplastic neurologic syndromes. Neurol Neuroimmunol Neuroinflamm 8: e1014, 2021 ［doi: 10.1212/NXI.0000000000001014］
2)Vogrig A, Gigli GL, Segatti S, Corazza E, Marini A, et al: Epidemiology of paraneoplastic neurological syndromes: a population-based study. J Neurol 267: 26-35, 2020
3)Hébert J, Riche B, Vogrig A, Muñiz-Castrillo S, Joubert B, et al: Epidemiology of paraneoplastic neurologic syndromes and autoimmune encephalitides in France. Neurol Neuroimmunol Neuroinflamm 7: e883, 2020 ［doi: 10.1212/NXI.0000000000000883］
4)Graus F, Keime-Guibert F, Reñe R, Benyahia B, Ribalta T, et al: Anti-Hu-Associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain 124: 1138-1148, 2001
5)Peterson K, Rosenblum MK, Kotanides H, Posner JB: Paraneoplastic cerebellar degeneration: I: a clinical analysis of 55 anti-Yo antibody-positive patients. Neurology 42:1931-1937, 1992
6)Honnorat J, Cartalat-Carel S, Ricard D, Camdessanche JP, Carpentier AF, et al: Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with HU or CV2/CRMP5 antibodies. J Neurol Neurosurg Psychiatry 80: 412-416, 2009
7)Dalmau J, Graus F, Villarejo A, Posner JB, Blumenthal D, et al: Clinical analysis of anti-Ma2-associated encephalitis. Brain 127: 1831-1844, 2004
8)Pittock SJ, Lucchinetti CF, Parisi JE, Benarroch EE, Mokri B, et al: Amphiphysin autoimmunity: paraneoplastic accompaniments. Ann Neurol 58: 96-107, 2005
9)Evergren E, Marcucci M, Tomilin N, Löw P, Slepnev V, et al: Amphiphysin is a component of clathrin coats formed during synaptic vesicle recycling at the lamprey giant synapse. Traffic 5: 514-528, 2004
10)Luque FA, Furneaux HM, Ferziger R, Rosenblum MK, Wray SH, et al: Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann Neurol 29: 241-251, 1991
11)Pittock SJ, Parisi JE, McKeon A, Roemer SF, Lucchinetti CF, et al: Paraneoplastic jaw dystonia and laryngospasm with antineuronal nuclear autoantibody type 2 (anti-Ri). Arch Neurol 67: 1109-1115, 2010
12)Feldheim J, Deuschl C, Glas M, Kleinschnitz C, Hagenacker T: Simultaneous paraneoplastic cerebellar degeneration, Lambert-Eaton syndrome and neuropathy associated with AGNA/ anti-SOX1 and VGCC antibodies. Neurol Res Pract 3: 30, 2021 ［doi: 10.1186/s42466-021-00129-w］
13)Giometto G, Grisold W, Vitaliani R, Graus F, Honnorat J, et al; PNS Euronetwork: Paraneoplastic neurologic syndrome in the PNS Euronetwork database: a European study from 20 centers. Arch Neurol 67: 330-335, 2010
receptor autoantibody frequency in service serologic evaluation. Neurology 81: 882-887, 2013
15)Höftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, et al: Encephalitis and AMPA receptor antibodies: novel findings in a case series of 22 patients. Neurology 84: 2403-2412, 2015
receptor antibody-associated encephalitis. Neurology 88: 1012-1020, 2017
17)Dalmau J, Graus F: Antibody-mediated encephalitis. N Engl J Med 378: 840-851, 2018
18)Tanaka K, Tani T, Ogawa K, Kinoshita M, Tanaka M: Trial of cytotoxic T cell induction in mice as an ex vivo model of paraneoplastic neurologic syndrome with anti-Hu antibodies. Clin Exp Neuroimmunol 13: 316-322, 2022
19)Dalmau J, Geis C, Graus F: Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system. Physiol Rev 97: 839-887, 2017
20)Small M, Treilleux I, Couillault C, Pissaloux D, Picard G, et al: Genetic alterations and tumor immune attack in Yo paraneoplastic cerebellar degeneration. Acta Neuropathol 135: 569-579, 2018
21)Rojas-Marcos I, Picard G, Chinchón D, Gelpi E, Psimaras D, et al: Human epidermal growth factor receptor 2 overexpression in breast cancer of patients with anti-Yo-associated paraneoplastic cerebellar degeneration. Neuro Oncol 14: 506-510, 2012
22)de Pemille, Berzero G, Small M, Psimaras D, Giry M, et al: Transcriptomic immune profiling of ovarian cancers in paraneoplastic cerebellar degeneration associated with anti-Yo antibodies. Br J Cancer 119: 105-113, 2018
23)Chefdeville A, Treilleux I, Mayeur ME, Couillault C, Picard G, et al: Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis. Acta Neuropathol Commun 7: 38, 2019 ［doi: 10.1186/s40478-019-0693-7］
24)Day GS, Laiq S, Tang-Wai DF, Munoz DG: Abnormal neurons in teratomas in NMDAR encephalitis. JAMA Neurol 71: 717-724, 2014
25)Ishigaki K, Lagattuta KA, Luo Y, James EA, Buckner JH, et al: HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors. Nat Genet 54: 393-402, 2022
26)Tani T, Tanaka K, Idezuka J, Nishizawa M: Regulatory T cells in paraneoplastic neurological syndromes. J Neuroimmunol 196: 166-169, 2008
27)Duong SL, Prüss H: Paraneoplastic autoimmune neurological syndromes and the role of immune checkpoint inhibitors. Neurotherapeutics 19: 848-863, 2022
28)Déchelotte B, Muñiz-Castrillo S, Joubert B, Vogrig A, Picard G, et al: Diagnostic yield of commercial immunodots to diagnose paraneoplastic neurologic syndromes. Neurol Neuroimmunol Neuroinflamm 7: e701, 2020 ［doi: 10.1212/NXI.0000000000000701］
29)Flanagan EP, Geschwind MD, Lopez-Chiriboga AS, Blackburn KM, Turaga S, et al: Autoimmune encephalitis misdiagnosis in adults. JAMA Neurol 80: 30-39, 2023
30)Tanaka K, Kitagawa Y, Hori K, Kinoshita M, Tanaka M: Evaluation of the concordance between GluN1-GluN2 heteromer live-cell-based assay and GluN1 monomer biochip kit assay on anti-NMDAR autoantibody detection. J Immunol Methods 499: 113150, 2021 ［doi: 10.1016/j.jim.2021.113150］
掲載誌情報
