BRAIN and NERVE－神経研究の進歩75巻6号

2023年06月発行

総説

慢性外傷性脳症の生前画像診断に向けての取組み

著者： 宮田真里¹ 高畑圭輔¹

所属機関： ¹国立研究開発法人量子科学技術研究開発機構 量子医科学研究所脳機能イメージング研究部 脳疾患トランスレーショナル研究チーム

ページ範囲：P.769 - P.778

文献概要

脳震盪や頭部への打撃を繰り返し負ったスポーツ選手において，数年から数十年の月日を経た後，記憶障害や抑うつ症状，パーキンソン症状などの神経精神症状や運動障害が出現することがある。その発症機序として，慢性外傷性脳症（chronic traumatic encephalopathy：CTE）の関与が知られている。本論ではCTEを中心に頭部外傷の遅発性脳障害に関する臨床的・神経病理学的特徴を紹介し，タウPETやMRIによる生前診断法の確立に向けたわれわれの取組みについて紹介する。

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