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特集 アルツハイマー病は本当に早期発見できるのか
文献概要
前臨床期アルツハイマー病（Alzheimer's disease：AD）を発見するための臨床的バイオマーカーは脳脊髄液やPETなどのバイオマーカーに比してまだまだ研究が遅れている。現在までのAD早期発見のチェックリストは前臨床期ADの発見には概してあまり役立たない。むしろ日常生活活動や言語能力を評価することが推奨される。さらに，AD発症のリスクとされている因子（独居・社会的孤立や難聴，嗅覚低下，歯の喪失，体重変化，アパシー／抑うつ，これらの組合せ）に着眼する。
参考文献
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