BRAIN and NERVE－神経研究の進歩76巻1号

2024年01月発行

特集 新時代の重症筋無力症と関連疾患の診療

臨床で遭遇するdouble seronegative重症筋無力症—実態と病態を考察する

著者： 近藤誉之¹

所属機関： ¹関西医科大学総合医療センター脳神経内科

ページ範囲：P.55 - P.60

文献概要

アセチルコリン受容体（acetylcholine receptor：AChR）抗体，筋特異的チロシンキナーゼ（muscle-specific tyrosine kinase：MuSK）抗体が既存法で陰性の重症筋無力症（myasthenia gravis：MG）は，DNMG（double seronegative MG）とされる。Cell-based assayでAChR抗体，MuSK抗体の関与が証明される症例もある。検査上，AChR抗体の検出されないAChR抗体関与症例は多く，両抗体の関与しない重症DNMG例も存在すると推測される。

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