BRAIN and NERVE－神経研究の進歩76巻1号

2024年01月発行

特集 新時代の重症筋無力症と関連疾患の診療

神経筋接合部（NMJ）の形成・維持シグナルとNMJ標的治療の開発

著者： 山内（井上）茜¹ 山梨裕司¹

所属機関： ¹東京大学医科学研究所癌・細胞増殖部門腫瘍抑制分野

ページ範囲：P.61 - P.67

文献概要

骨格筋は個体の運動機能，認知機能や多様な臓器の健全性に必須の器官であり，骨格筋機能を支える筋収縮は運動神経による厳密な制御を受ける。運動神経軸索末端と筋管（筋線維）を結ぶ神経筋接合部（neuromuscular junction：NMJ）は骨格筋収縮の運動神経支配に必須の化学シナプスであり，その異常は筋力低下を含む多様な骨格筋機能の異常を引き起こす。本稿では骨格筋におけるNMJ形成・維持シグナルの理解とNMJ標的治療開発の概要を紹介する。

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