BRAIN and NERVE－神経研究の進歩76巻2号

2024年02月発行

特集 特発性正常圧水頭症の現在

特発性正常圧水頭症の疫学・自然歴と遺伝

著者： 伊関千書¹²

所属機関： ¹東北大学大学院医学系研究科高次機能障害学分野 ²山形大学医学部内科学第三講座神経内科学分野

ページ範囲：P.123 - P.126

文献概要

わが国の疫学調査で，特発性正常圧水頭症（idiopathic normal pressure hydrocephalus：iNPH）は80代高齢住民のうち7.7％の有病率である一方，受診率は数％と低い。iNPHでは，発症数年前からAVIM（asymptomatic ventriculomegaly with features of iNPH on MRI）もしくはAVE（asymptomatic ventricular enlargement）の状態が認められる自然歴がある。SFMBT1遺伝子がリスク遺伝子の1つである。

参考文献

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