BRAIN and NERVE－神経研究の進歩76巻2号

2024年02月発行

特集 特発性正常圧水頭症の現在

特発性正常圧水頭症の鑑別診断—特に進行性核上性麻痺

著者： 大原正裕¹²

所属機関： ¹東京医科歯科大学大学院医歯学総合研究科脳神経病態学分野 ²

ページ範囲：P.127 - P.134

文献概要

特発性正常圧水頭症（idiopathic normal pressure hydrocephalus：iNPH）は，特徴的な画像所見や症状，シャント術への反応性に基づいて診断される。しかし，iNPHに類似した画像所見は神経変性疾患でも見られることがある。そのため，特に神経変性疾患の病初期でその疾患に特徴的な症状が顕在化していない段階においては，iNPHとの鑑別が困難であることが多い。本論では，iNPHの鑑別診断として進行性核上性麻痺を中心に概説し，shamタップテストを含めた評価プロトコルについて紹介する。

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