BRAIN and NERVE－神経研究の進歩76巻4号

2024年04月発行

特集 神経病理最前線

神経変性疾患の神経病理

著者： 岩崎靖¹

所属機関： ¹愛知医科大学加齢医科学研究所

ページ範囲：P.343 - P.351

文献概要

神経変性疾患の確定診断には病理学的検索が必須である。疾患ごとに障害される部位や系統は異なり，神経細胞脱落やグリオーシスなどの退行性変化，異常蛋白の蓄積，特徴的な凝集体の形成を認める。蓄積蛋白による分類では，タウ蛋白，α-シヌクレイン，TDP-43（TAR DNA-binding protein of 43kDa）が蓄積する疾患を，それぞれタウオパチー，α-シヌクレイノパチー，TDP-43プロテイノパチーと呼ぶ。

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