BRAIN and NERVE－神経研究の進歩76巻5号

2024年05月発行

増大特集 末梢神経・筋肉の自己免疫性・炎症性疾患ハンドブック

第2章　疾患各論

自己免疫性ノドパチー

著者： 緒方英紀¹

所属機関： ¹九州大学病院脳神経内科

ページ範囲：P.534 - P.539

文献概要

自己免疫性ノドパチー（autoimmune nodopathy）はランヴィエ絞輪部および傍絞輪部に局在する膜蛋白（neurofascin 186，neurofascin 155，contactin-1，contactin-associated protein 1）に対する自己抗体が陽性となる免疫介在性ニューロパチーである。同疾患は免疫グロブリン療法の効果が乏しくリツキシマブが奏効するため，関連する自己抗体を測定することは，診断のみならず治療方針を決定するうえで重要な役割を果たす。

参考文献

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