BRAIN and NERVE－神経研究の進歩76巻5号

2024年05月発行

増大特集 末梢神経・筋肉の自己免疫性・炎症性疾患ハンドブック

第2章　疾患各論

封入体筋炎

著者： 青木正志¹ 井泉瑠美子¹ 鈴木直輝¹

所属機関： ¹東北大学大学院医学系研究科神経内科学分野

ページ範囲：P.660 - P.670

文献概要

封入体筋炎は中高年に発症する特発性の筋疾患である。左右非対称の筋力低下と筋萎縮が大腿四頭筋や手指・手首屈筋に見られる。骨格筋には縁取り空胞と呼ばれる特徴的な組織変化を生じ炎症細胞浸潤を伴う。炎症性筋疾患に分類されるが，筋の「変性疾患」としての側面を持つ。ステロイドなどの免疫学的治療に反応せず，かえって増悪することもある。厚生労働省研究班による全国調査によるとわが国でも患者数が増加している。

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42）難治性疾患等政策研究事業 希少難治性筋疾患に関する調査研究班 封入体筋炎分科会（編）: 封入体筋炎 診療の手引き 2023年改訂版.　https://www.neurology-jp.org/guidelinem/pdf/syounin_17.pdf（最終閲覧日: 2024年2月9日）