BRAIN and NERVE－神経研究の進歩76巻7号

2024年07月発行

特集 ニューロ・バイオイメージング—技術と応用

2光子顕微鏡による神経活動の多重スケールイメージング

著者： 喜多村和郎¹

所属機関： ¹山梨大学大学院総合研究部医学域生理学講座神経生理学

ページ範囲：P.799 - P.805

文献概要

2光子カルシウムイメージングは，動物の脳における神経活動観察法の1つとして広く用いられている。近年，2光子顕微鏡やカルシウム指示分子の改良などにより高感度化や高速化，広視野化が進み，動物個体脳内に3次元的に存在する神経細胞の活動をマイクロメートルからミリメートルのスケールで大規模に観察することが可能になっている。本論では，これらの新しい2光子観察法とその神経科学へのアプリケーションを紹介する。

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