BRAIN and NERVE－神経研究の進歩76巻7号

2024年07月発行

特集 ニューロ・バイオイメージング—技術と応用

Hyperscanning fMRIによる社会能力神経基盤へのアプローチ

著者： 定藤規弘¹

所属機関： ¹立命館大学総合科学技術研究機構

ページ範囲：P.843 - P.850

文献概要

Hyperscanning fMRIは社会能力の神経基盤探求を動機として開発された。複数被験者の脳活動を同時に撮像することにより，リアルタイムの相互作用やコミュニケーションの神経基盤を解析することが可能となった。個体に還元できない現象としての個体間同期を始めとして，社会的な相互作用の神経基盤を明らかにする方法であり，私たちの生活の大部分を占める社会的相互作用を支える神経メカニズムの研究を可能にしつつある。従前の個体と環境の間の相互作用としての「一人称」の脳科学から，個人間の関係性を脳科学的手法で研究するという意味での「二人称」の脳科学へと展開するうえで，重要な方法論の1つとなり得る。開発の背景，現状と将来展望について概説する。

参考文献

1）Ogawa S, Lee TM, Kay AR, Tank DW: Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 87: 9868-9872, 1990

2）Villringer A, Planck J, Hock C, Schleinkofer L, Dirnagl U: Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults. Neurosci Lett 154: 101-104, 1993

3）Toyoda H, Kashikura K, Okada T, Nakashita S, Honda M, et al: Source of nonlinearity of the BOLD response revealed by simultaneous fMRI and NIRS. Neuroimage 39: 997-1013, 2008

4）Montague PR, Berns GS, Cohen JD, McClure SM, Pagnoni G, et al: Hyperscanning: simultaneous fMRI during linked social interactions. NeuroImage 16: 1159-1164, 2002

5）Czeszumski A, Eustergerling S, Lang A, Menrath D, Gerstenberger M, et al: Hyperscanning: a valid method to study neural inter-brain underpinnings of social interaction. Front Hum Neurosci 14: 39, 2020［doi: 10.3389/fnhum.2020.00039］

6）Hakim U, De Felice S, Pinti P, Zhang X, Noah JA, et al: Quantification of inter-brain coupling: A review of current methods used in haemodynamic and electrophysiological hyperscanning studies. Neuroimage 280: 120354, 2023［doi: 10.1016/j.neuroimage.2023.120354］

7）Trevarthen C: Communication and cooperation in early infancy: a description of primary intersubjectivity. Bullowa M (ed): Before Speech: The Beginning of Interpersonal Communication. Cambridge University Press, Cambridge, 1979, pp321-347

8）Atzil S, Gao W, Fradkin I, Barrett LF: Growing a social brain. Nat Hum Behav 2: 624-636, 2018

9）鯨岡 峻: ひとがひとをわかるということ: 間主観性と相互主体性. ミネルヴァ書房, 京都, 2006

10）Tomasello M: Constructing a Language: A Usage-Based Theory of Language Acquisition. Harvard University Press, Cambridge, 2003

11）Miyata K, Koike T, Nakagawa E, Harada T, Sumiya M, et al: Neural substrates for sharing intention in action during face-to-face imitation. Neuroimage 233: 117916, 2021［doi: 10.1016/j.neuroimage.2021.117916］

12）Saito DN, Tanabe HC, Izuma K, Hayashi MJ, Morito Y, et al: “Stay Tuned”: inter-individual neural synchronization during mutual gaze and joint attention. Front Integr Neurosci 4: 127, 2010［doi: 10.3389/fnint.2010.00127］

13）Tanabe HC, Kosaka H, Saito DN, Koike T, Hayashi MJ, et al: Hard to “tune in”: neural mechanisms of live face-to-face interaction with high-functioning autistic spectrum disorder. Front Hum Neurosci 6: 268, 2012［doi: 10.3389/fnhum.2012.00268］

14）Koike T, Tanabe HC, Okazaki S, Nakagawa E, Sasaki AT, et al: Neural substrates of shared attention as social memory: a hyperscanning functional magnetic resonance imaging study. Neuroimage 125: 401-412, 2016［doi: 10.1016/j.neuroimage.2015.09.076］

15）Koike T, Tanabe HC, Adachi-Abe S, Okazaki S, Nakagawa E, et al: Role of the right anterior insular cortex in joint attention-related identification with a partner. Soc Cogn Affect Neurosci 14: 1131-1145, 2019［doi: 10.1093/scan/nsz087］

16）Yoshioka A, Tanabe HC, Sumiya M, Nakagawa E, Okazaki S, et al: Neural substrates of shared visual experiences: a hyperscanning fMRI study. Soc Cogn Affect Neurosci 16: 1264-1275, 2021［doi: 10.1093/scan/nsab082］

17）定藤規弘: 対面コミュニケーションにより生じる社会的相互作用の神経基盤. 日心療内誌26(suppl): 40, 2022

18）Misaki M, Kerr KL, Ratliff EL, Cosgrove KT, Simmons WK, et al: Beyond synchrony: the capacity of fMRI hyperscanning for the study of human social interaction. Soc Cogn Affect Neurosci 16: 84-92, 2021

19）Gordon I, Wallot S, Berson Y: Group-level physiological synchrony and individual-level anxiety predict positive affective behaviors during a group decision-making task. Psychophysiology 58: e13857, 2021［doi: 10.1111/psyp.13857］

20）Harel H, Gordon I, Geva R, Feldman R: Gaze behaviors of preterm and full-term infants in nonsocial and social contexts of increasing dynamics: visual recognition, attention regulation, and gaze synchrony. Infancy 16: 69-90, 2011

21）Mogan R, Fischer R, Bulbulia JA: To be in synchrony or not? A meta-analysis of synchrony's effects on behavior, perception, cognition and affect. J Exp Soc Psychol 72: 13-20, 2017

22）Müller VI, Cieslik EC, Laird AR, Fox PT, Eickhoff SB: Dysregulated left inferior parietal activity in schizophrenia and depression: functional connectivity and characterization. Front Hum Neurosci 7: 268, 2013［doi: 10.3389/fnhum.2013.00268］

23）Reindl V, Wass S, Leong V, Scharke W, Wistuba S, et al: Multimodal hyperscanning reveals that synchrony of body and mind are distinct in mother-child dyads. Neuroimage 251: 118982, 2022［doi: 10.1016/j.neuroimage.2022.118982］

24）Pan Y, Novembre G, Song B, Zhu Y, Hu Y: Dual brain stimulation enhances interpersonal learning through spontaneous movement synchrony. Soc Cogn Affect Neurosci 16: 210-221, 2021［doi: 10.1093/scan/nsaa080］

25）Wiltermuth SS, Heath C: Synchrony and cooperation. Psychol Sci 20: 1-5, 2009

26）Reinero DA, Dikker S, Van Bavel JJ: Inter-brain synchrony in teams predicts collective performance. Soc Cogn Affect Neurosci 16: 43-57, 2021

27）Lotter LD, Kohl SH, Gerloff C, Bell L, Niephaus A, et al: Revealing the neurobiology underlying interpersonal neural synchronization with multimodal data fusion. Neurosci Biobehav Rev 146: 105042, 2023［doi: 10.1016/j.neubiorev.2023.105042］

28）Fries P: A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn Sci 9: 474-480, 2005

29）Uhlhaas PJ, Singer W: Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology. Neuron 52: 155-168, 2006

30）Llinás RR, Steriade M: Bursting of thalamic neurons and states of vigilance. J Neurophysiol 95: 3297-3308, 2006

31）Gvirts Probolovski HZ: Commentary: using second-person neuroscience to elucidate the mechanisms of reciprocal social interaction. Front Behav Neurosci 14: 13, 2020［doi: 10.3389/fnbeh.2020.00013］

32）Hamilton AFC: Hyperscanning: beyond the hype. Neuron 109: 404-407, 2021

33）Tessari A, Canessa N, Ukmar M, Rumiati RI: Neuropsychological evidence for a strategic control of multiple routes in imitation. Brain 130: 1111-1126, 2007［doi: 10.1093/brain/awm003］

34）Lakin JL, Chartland TL: Using nonconscious behavioral mimicry to create affiliation and rapport. Psychol Sci 14: 334-339, 2003

35）Friston K, Frith C: A duet for one. Conscious Cogn 36: 390-405, 2015

36）Mende MA, Schmidt H: Psychotherapy in the framework of embodied cognition: does interpersonal synchrony influence therapy success? Front Psychiatry 12: 562490, 2021［doi: 10.3389/fpsyt.2021.562490］

37）Anzolin A, Isenburg K, Grahl A, Toppi J, Yucel M, et al: Patient-clinician brain response during clinical encounter and pain treatment. Annu Int Conf IEEE Eng Med Biol Soc 2020: 1512-1515, 2020

38）Ellingsen DM, Isenburg K, Jung C, Lee J, Gerber J, et al: Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction. Sci Adv 6: eabc1304, 2020［doi: 10.1126/sciadv.abc1304］

39）Xie H, Karipidis II, Howell A, Schreier M, Sheau KE, et al: Finding the neural correlates of collaboration using a three-person fMRI hyperscanning paradigm. Proc Natl Acad Sci U S A 117: 23066-23072, 2020

40）Harrison SJ, Woolrich MW, Robinson EC, Glasser MF, Beckmann CF, et al: Large-scale probabilistic functional modes from resting state fMRI. Neuroimage 109: 217-231, 2015

41）Harrison SJ, Bijsterbosch JD, Segerdahl AR, Fitzgibbon SP, Farahibozorg SR, et al: Modelling subject variability in the spatial and temporal characteristics of functional modes. Neuroimage 222: 117226, 2020［doi: 10.1016/j.neuroimage.2020.117226］

42）Rubinov M, Sporns O: Complex network measures of brain connectivity: uses and interpretations. Neuroimage 52: 1059-1069, 2010

43）Said A, Bayrak RG, Derr T, Shabbir M, Moyer D, et al: Neurograph: benchmarks for graph machine learning in brain connectomics. arXiv: 2306.06202v3, 2023［doi: 10.48550/arXiv.2306.06202］

44）Wang LS, Cheng JT, Hsu IJ, Liou S, Kung CC, et al: Distinct cerebral coherence in task-based fMRI hyperscanning: cooperation versus competition. Cereb Cortex 33: 421-433, 2022

45）Brookes MJ, Leggett J, Rea M, Hill RM, Holmes N, et al: Magnetoencephalography with optically pumped magnetometers (OPM-MEG): the next generation of functional neuroimaging. Trends Neurosci 45: 621-634, 2022

46）Redcay E, Schilbach L: Using second-person neuroscience to elucidate the mechanisms of social interaction. Nat Rev Neurosci 20: 495-505, 2019