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総合診療31巻4号

2021年04月発行

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特集 消化器診療“虎の巻”—あなたの切実なギモンにズバリ答えます! 【消化管】

Q1 逆流性食道炎に対するPPIはどの時点で中止してよいの?

著者: 青島周一1

所属機関: 1医療法人社団 徳仁会 中野病院 薬剤部

ページ範囲:P.418 - P.420

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逆流性食道炎に対するプロトンポンプ阻害薬(proton pump inhibitor:PPI)は、「中止」「継続」という二分法ではなく、患者個別の状況に応じて多面的な視点で評価を行いたい。

参考文献

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-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. Cochrane Database Syst Rev 2013(5) : CD002095, 2013. PMID 23728637
3)Reimer C, et al : Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology 137(1) : 80-87, 87.e1, 2009. PMID 19362552
4)Kinoshita Y, et al : Advantages and disadvantages of long-term proton pump inhibitor use. J Neurogastroenterol Motil 24(2) : 182-196, 2018. PMID 29605975
5)Farrell B, et al : Deprescribing proton pump inhibitors ; evidence-based clinical practice guideline. Can Fam Physician 63(5) : 354-364, 2017. PMID 28500192
6)Thompson W, et al : Patient values and preferences surrounding proton pump inhibitor use ; a scoping review. Patient 11(1) : 17-28, 2018. PMID 28608038
7)Thompson W, et al : Effect of a proton pump inhibitor deprescribing guideline on drug usage and costs in long-term care. J Am Med Dir Assoc 17(7) : 673. e1-4, 2016. PMID 27289201
8)Björnsson E, et al : Discontinuation of proton pump inhibitors in patients on long-term therapy ; a double-blind, placebo-controlled trial. Aliment Pharmacol Ther 24(6) : 945-954, 2006. PMID 16948806
9)Boghossian TA, et al : Deprescribing versus continuation of chronic proton pump inhibitor use in adults. Cochrane Database Syst Rev 3(3) : CD011969, 2017. PMID 28301676
10)Bundeff AW, et al : Impact of clinical pharmacists' recommendations on a proton pump inhibitor taper protocol in an ambulatory care practice. J Manag Care Pharm 19(4) : 325-333, 2013. PMID 23627578
11)Tandun R, et al : Who has the guts to deprescribe proton pump inhibitors? ; a pharmacist-led intervention in a long-term care facility setting. Aging Med (Milton) 2(2) : 112-117, 2019. PMID 31942521

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2188-806X

印刷版ISSN:2188-8051

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