循環器ジャーナル65巻3号

2017年07月発行

特集 不整脈診療—ずっと疑問・まだ疑問 Ⅰ．不整脈診療のベーシック

心室不整脈のトライアル：「絶対の3つ」と「大事な9つ」

著者： 橋田匡史¹ 吉岡公一郎¹

所属機関： ¹東海大学医学部内科学系循環器内科

ページ範囲：P.431 - P.439

Point
・心室不整脈治療は，患者の不整脈起源となった病態を把握したうえで，治療法を選択することが重要である．
・心室不整脈を対象とした様々な臨床試験を通じて，心疾患患者の生命予後の改善を図ることが重要である．

参考文献

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5) Amiodarone Trials Meta-Analysis Investigators:Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure:meta-analysis of individual data from 6500 patients in randomised trials. Lancet 350:1417-1424, 1997

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7) Moss AJ, Hall WJ, Cannom DS, et al:Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med 335:1933-1940, 1996

8) Moss AJ, Zareba W, Hall WJ, et al:Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 346:877-883, 2002

9) Buxton AE, Lee KL, Fisher JD, et al:A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators. N Engl J Med 341:1882-1890, 1999

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11) Kadish A, Dyer A, Daubert JP, et al:Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med 350:2151-2158, 2004

12) Bänsch D, Antz M, Boczor S, et al:Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy:the Cardiomyopathy Trial（CAT）. Circulation 105:1453-1458, 2002

13) Strickberger SA, Hummel JD, Bartlett TG, et al;AMIOVIRT Investigators:Amiodarone versus implantable cardioverter-defibrillator:randomized trial in patients with nonischemic dilated cardiomyopathy and asymptomatic nonsustained ventricular tachycardia-AMIOVIRT. J Am Coll Cardiol 41:1707-1712, 2003

14) Bardy GH, Lee KL, Mark DB, et al:Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352:225-237, 2005

15) Powell BD, Saxon LA, Boehmer JP, et al:Survival after shock therapy in implantable cardioverter-defibrillator and cardiac resynchronization therapy-defibrillator recipients according to rhythm shocked. The ALTITUDE survival by rhythm study. J Am Coll Cardiol 62:1674-1679, 2013

16) Moss AJ, Schuger C, Beck CA, et al;MADIT-RIT trial investigators:Reduction in inappropriate therapy and mortality through ICD programming. N Engl J Med 367:2275-2283, 2012