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文献詳細

雑誌文献

循環器ジャーナル65巻4号

2017年10月発行

文献概要

特集 ACSの診断と治療はどこまで進歩したのか Ⅳ.ACSの二次予防

抗血小板療法,DAPT

著者: 飯島雷輔1

所属機関: 1東邦大学医療センター大橋病院循環器内科

ページ範囲:P.659 - P.665

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・ACSに薬物溶出性ステント治療後にDAPTは少なくとも12カ月継続が推奨されている.
・ACSを対象とした新世代の薬物溶出性ステントでの無作為試験の臨床成績はない.
・DAPT試験は,長期DAPTの有効性を示した臨床試験だが,ステント治療に続く1年間にイベントのない症例での検討である.
・DAPT試験からACS患者では,特に長期DAPT継続のメリットがあることが示された.

参考文献

1) Levine GN, Bates ER, Bittl JA, et al:2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease:a report of the American college of Cardiology/American heart association task force on clinical practice guidelines. J Am Coll Cardiol 68:1082-1115, 2016
2) Pfisterer M, Brunner-La Rocca HP, Buser PT, et al:Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents:an observational study of drug-eluting versus bare-metal stents. J Am Coll Cardiol 48:2584-2591, 2006
3) Valgimigli M, Campo G, Monti M, et al:Short-versus long-term duration of dual-antiplatelet therapy after coronary stenting:a randomized multicenter trial. Circulation 125:2015-2026, 2012
4) Gilard M, Barragan P, Noryani AA, et al:6-versus 24-month dual antiplatelet therapy after implantation of drug-eluting stents in patients nonresistant to aspirin:the randomized, multicenter ITALIC trial. J Am Coll Cardiol 65:777-786, 2014
5) Colombo A, Chieffo A, Frasheri A, et al:Second-generation drug-eluting stent implantation followed by 6-versus 12-month dual antiplatelet therapy:the SECURITY randomized clinical trial. J Am Coll Cardiol 64:2086-2097, 2014
6) Schulz-Schupke S, Byrne RA, Ten Berg JM, et al:ISAR-SAFE:a randomized, double-blind, placebo-controlled trial of 6 vs. 12 months of clopidogrel therapy after drug-eluting stenting. Eur Heart J 36:1252-1263, 2015
7) Mauri L, Kereiakes DJ, Yeh RW, et al:Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med 371:2155-2166, 2014
8) Yeh RW, Kereiakes DJ, Steg PG, et al:Benefits and Risks of Extended Duration Dual Antiplatelet Therapy After PCI in Patients With and Without Acute Myocardial Infarction. J Am Coll Cardiol 65:2211-2221, 2015
9) Windecker S, Kolh P, Alfonso F, et al:2014 ESC/EACTS Guidelines on myocardial revascularization:the Task Force on Myocardial Revascularizationof the European Society of Cardiology(ESC)and the European Association for Cardio-Thoracic Surgery(EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions(EAPCI). Eur Heart J 35:2541-2619, 2014
10) Yusuf S, Zhao F, Mehta SR, et al:Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345:494-502, 2001
11) Palmerini T, Della Riva D, Benedetto U, et al:Three, six, or twelve months of dual antiplatelet therapy after DES implantation in patients with or without acute coronary syndromes:an individual patient data pairwise and network meta-analysis of six randomized trials and 11 473 patients. Eur Heart J 38:1034-1043, 2017
12) Nakamura M, Iijima R, Ako J, et al:6 months versus 18 months dual antiplatelet treatment for patients underwent bioabsorbable polymer and abluminal coated DES deployment:NIPPON randomized study. JACC Intev, in press.

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2432-3292

印刷版ISSN:2432-3284

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