循環器ジャーナル68巻1号

2020年01月発行

特集 U40世代が描く心不全診療の現状と未来—基礎研究を識り，臨床を素心深考する Ⅰ．心筋症

—基礎編—虚血性心筋症：急性心筋梗塞後のリモデリングの規定因子とリモデリングを抑制する方法はありますか？

著者： 高橋佑典¹ 木岡秀隆¹ 坂田泰史¹

所属機関： ¹大阪大学大学院医学系研究科循環器内科学

ページ範囲：P.36 - P.40

Point
・心筋梗塞後の左室リモデリングは，梗塞領域の創傷治癒にかかわる早期リモデリングと慢性期の左室機能低下にかかわる後期リモデリングに分けられる．
・早期リモデリングには炎症と組織修復という2相性の反応が必要で，不十分な創傷治癒や過剰な炎症は，後期リモデリングをも増悪させる．
・早期リモデリングに着目した，免疫細胞や心筋代謝に介入する新規治療法の臨床応用が期待される．

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