循環器ジャーナル68巻1号

2020年01月発行

特集 U40世代が描く心不全診療の現状と未来—基礎研究を識り，臨床を素心深考する Ⅱ．その他

—臨床編—肺高血圧症の病態に応じた薬剤の使い分けはありますか？

著者： 古川明日香¹ 田村雄一¹

所属機関： ¹国際医療福祉大学三田病院肺高血圧症センター

ページ範囲：P.110 - P.116

Point
・肺高血圧症は使用可能な薬剤が増え，治療法がない時代よりは予後は改善しているとはいえ，まだまだ十分ではない．
・予後改善のためには，必要な症例に時期を逸することなく適切な治療を開始することが重要である．

参考文献

1) Simonneau G, Montani D, Celermajer DS, et al:Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J 53. pii:1801913, 2019

2) Hoeper MM, Huscher D, Ghofrani HA, et al:Elderly patients diagnosed with idiopathic pulmonary arterial hypertension:results from the COMPERA registry. Int J Cardiol 168:871-880, 2013

3) D' Alonzo GE, Barst RJ, Ayres SM, et al:Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 115:343-349, 1991

4) Okada O, Tanabe N, Yasuda J, et al:Prediction of life expectancy in patients with primary pulmonary hypertension. A retrospective nationwide survey from 1980-1990. Intern Med 38:12-16, 1999

5) Humbert M, Sitbon O, Yaïci A, et al:Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension. Eur Respir J 36:549-555, 2010

6) Benza RL, Miller DP, Barst RJ, et al:An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest 142:448-456, 2012

7) Galiè N, Humbert M, Vachiery JL, et al:2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J 37:67-119, 2016

8) Galiè N, Channick RN, Frantz RP, et al:Risk stratification and medical therapy of pulmonary arterial hypertension. Eur Respir J 53. pii:1801889, 2019

9) Ogawa A, Ejiri K, Matsubara H:Long-term patient survival with idiopathic/heritable pulmonary arterial hypertension treated at a single center in Japan. Life Sci 118:414-419, 2014

10) Tamura Y, Kumamaru H, Satoh T, et al:Effectiveness and Outcome of Pulmonary Arterial Hypertension-Specific Therapy in Japanese Patients with Pulmonary Arterial Hypertension. Circ J 82:275-282, 2017

11) Simonneau G, Barst RJ, Galie N, et al:Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension:a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 165:800-804, 2002

12) Opitz CF, Hoeper MM, Gibbs JS, et al:Pre-Capillary, Combined, and Post-Capillary Pulmonary Hypertension:A Pathophysiological Continuum. J Am Coll Cardiol 68:368-378, 2016