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雑誌文献

循環器ジャーナル68巻1号

2020年01月発行

文献概要

特集 U40世代が描く心不全診療の現状と未来—基礎研究を識り,臨床を素心深考する Ⅲ.臓器関連

—臨床編—脳:自律神経が血行動態に与える影響と病態はどのようなものですか?—自律神経による血行動態制御と心不全

著者: 坂本隆史1

所属機関: 1九州大学病院循環器内科

ページ範囲:P.122 - P.126

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・自律神経は様々な外乱に対して血行動態などの恒常性を保つための重要なシステムである.
・生体の様々な情報を求心性に脳に伝達し,交感神経や迷走神経が変化し,効果器による血行動態応答が起こる.
・心不全では,これらのいずれかの応答性の異常により最適なfeedback制御が破綻している.

参考文献

1) Sato T, Kawada M, Inagaki T, et al:Dynamics of sympathetic baroreflex control of arterial pressure in rats. Am J Physiol Regul Integr Comp Physiol 285:R262-R270, 2003
2) Floras JS:Sympathetic nervous system activation in human heart failure:clinical implications of an updated model. J Am Coll Cardiol 54:375-385, 2009
3) Marshall JM:Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev 74:543-594, 1994
4) Li YL, Li YF, Liu D, et al:Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits. Circ Res 97:260-267, 2005
5) Wang H, Parker JD, Newton GE, et al:Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am Coll Cardiol 49:1625-1631, 2007
6) Somers VK, Dyken ME, Clary MP, et al:Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96:1897-1904, 1995
7) Spaak J, Egri ZJ, Kubo T, et al:Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea. Hypertension 46:1327-1332, 2005
8) Nishi H, Demir E, Panchenko AR:Crosstalk between signaling pathways provided by single and multiple protein phosphorylation sites. J Mol Biol 427:511-520, 2015
9) Hirooka Y, Sagara Y, Kishi T, et al:Oxidative stress and central cardiovascular regulation. -Pathogenesis of hypertension and therapeutic aspects-. Circ J 74:827-835, 2010
10) Nakagaki T, Hirooka Y, Matsukawa R, et al:Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res 35:470-476, 2012
11) Isegawa K, Hirooka Y, Katsuki M, et al:Angiotensin Ⅱ type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure. Am J Physiol Heart Circ Physiol 307:H1448-H1455, 2014
12) Kenney MJ, Ganta CK:Autonomic nervous system and immune system interactions. Compr Physiol 4:1177-1200, 2014
13) Kang YM, Zhang ZH, Johnson RF, et al:Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure. Circ Res 99:758-766, 2006
14) Uemura K, Sugimachi M, Kawada T, et al:A novel framework of circulatory equilibrium. Am J Physiol Heart Circ Physiol 286:H2376-H2385, 2004
15) Kubota T, Alexander J Jr, Itaya R, et al:Dynamic effects of carotid sinus baroreflex on ventriculoarterial coupling studied in anesthetized dogs. Circ Res 70:1044-1053, 1992
16) Sakamoto T, Kakino T, Sakamoto K, et al:Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure. Am J Physiol Heart Circ Physiol 308:H49-58, 2015
17) John E. Hall, Guyton and Hall Textbook of Medical Physiology, 13 edition, Saunders, philadelphia 2015

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2432-3292

印刷版ISSN:2432-3284

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