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雑誌文献

循環器ジャーナル68巻1号

2020年01月発行

文献概要

特集 U40世代が描く心不全診療の現状と未来—基礎研究を識り,臨床を素心深考する Ⅲ.臓器関連

—基礎編—慢性腎臓病が心不全に及ぼす影響と病態はどのようなものですか?

著者: 尾上健児1

所属機関: 1奈良県立医科大学循環器内科

ページ範囲:P.140 - P.145

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・腎臓病と心血管疾患には密接な関係があり心腎症候群と呼ばれる.
・心腎症候群に関与する分子機序はこれまでに多数知られており,sFlt-1もkey moleculeの一つである.
・分子機序に基づく新たな治療戦略の構築が今後も求められる.

参考文献

1) Keith DS, Nichols GA, Gullion CM, et al:Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 164:659-663, 2004
2) Ronco C, Haapio M, House AA, et al:Cardiorenal Syndrome. J Am Coll Cardiol 52:1527-1539, 2008
3) Nakamura H, Tokumoto M, Mizobuchi M, et al:Novel markers of left ventricular hypertrophy in uremia. Am J Nephrol 31:292-302, 2010
4) Rebholz CM, Selvin E, Liang M, et al:Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease. Kidney Int 93:252-259, 2018
5) Chuppa S, Liang M, Liu P, et al:MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. Kidney Int 93:375-389, 2018
6) Shibuya M:Vascular endothelial growth factor receptor-1(VEGFR-1/Flt-1):a dual regulator for angiogenesis. Angiogenesis 9:225-230, 2006
7) Onoue K, Uemura S, Takeda Y, et al:Reduction of Circulating Soluble Fms-Like Tyrosine Kinase-1 Plays a Significant Role in Renal Dysfunction-Associated Aggravation of Atherosclerosis. Circulation 120:2470-2477, 2009
8) Matsumoto T, Uemura S, Takeda Y, et al:An elevated ratio of placental growth factor to soluble fms-like tyrosine kinase-1 predicts adverse outcomes in patients with stable coronary artery disease. Intern Med 52:1019-1027, 2013
9) Matsui M, Takeda Y, Uemura S, et al:Suppressed soluble Fms-like tyrosine kinase-1 production aggravates atherosclerosis in chronic kidney disease. Kidney Int 85:393-403, 2014
10) Nakada Y, Kawakami R, Matsui M, et al:Value of Placental Growth Factor as a Predictor of Adverse Events During the Acute Phase of Acute Decompensated Heart Failure. Circ J 83:395-400, 2019
11) Seno A, Takeda Y, Matsui M, et al:Suppressed Production of Soluble Fms-Like Tyrosine Kinase-1 Contributes to Myocardial Remodeling and Heart Failure. Hypertension 68:678-687, 2016

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2432-3292

印刷版ISSN:2432-3284

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