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雑誌文献

循環器ジャーナル68巻1号

2020年01月発行

文献概要

特集 U40世代が描く心不全診療の現状と未来—基礎研究を識り,臨床を素心深考する Ⅳ.基礎研究から知る臨床の未来

心筋再生はどこまで進んでいるの?

著者: 谷英典1 遠山周吾1

所属機関: 1慶應義塾大学医学部循環器内科

ページ範囲:P.165 - P.169

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・ヒトiPS細胞由来心筋細胞の移植は心移植の代替治療として期待される.
・心筋細胞の純化精製,大量生産法は移植の実現に向けた革新的な発明である.

参考文献

1) Takahashi K, Okita K, Nakagawa M, et al:Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2:3081-3089, 2007
2) Kattman SJ, Witty AD, Gagliardi M, et al:Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8:228-240, 2011
3) Dubois NC, Craft AM, Sharma P, et al:SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. Nature Biotechnology 29:1011-1018, 2011
4) Tohyama S, Hattori F, Sano M, et al:Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell 12:127-137, 2013
5) Tohyama S, Fujita J, Hishiki T, et al:Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells. Cell Metab 23:663-674, 2016
6) Tohyama S, Fukuda K:Safe and Effective Cardiac Regenerative Therapy With Human-Induced Pluripotent Stem Cells:How Should We Prepare Pure Cardiac Myocytes? Circ Res 120:1558-1560, 2017
7) Tohyama S, Fujita J, Fujita C, et al:Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes. Stem Cell Reports 9:1406-1414, 2017
8) Tabei R, Kawaguchi S, Kanazawa H, et al:Development of a transplant injection device for optimal distribution and retention of human induced pluripotent stem cell-derived cardiomyocytes. J Heart Lung Transplant 38:203-214, 2019
9) Liu YW, Chen B, Yang X, et al:Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates. Nat Biotechnol 36:597-605, 2018
10) Shiba Y, Gomibuchi T, Seto T, et al:Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts. Nature 538:388-391, 2016
11) Ieda M, Fu JD, Delgado-Olguin P, et al:Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142:375-386, 2010
12) Breckwoldt K, Letuffe-Breniere D, Mannhardt I, et al:Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat Protoc 12:1177-1197, 2017

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2432-3292

印刷版ISSN:2432-3284

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