icon fsr

文献詳細

雑誌文献

循環器ジャーナル68巻3号

2020年07月発行

文献概要

特集 不整脈治療の最新デバイステクノロジーとリードマネジメント Ⅰ.ペースメーカ

バイオペースメーカ

著者: 門田真12 柴祐司12

所属機関: 1信州大学先鋭領域融合研究群バイオメディカル研究所 2信州大学医学部再生医科学教室

ページ範囲:P.422 - P.427

文献購入ページに移動
Point
・遺伝子治療や細胞治療によるペースメーカ開発を目指した研究がある.
・自動能をもつように局所的に遺伝子を発現させる,もしくは細胞を移植する.
・将来的には機械式ペースメーカに代わる可能性がある.

参考文献

1) Furman S, Schwedel JB. An intracardiac pacemaker for Stokes-Adams seizures. N Engl J Med 261:943-948, 1959
2) DiFrancesco D, Tortora P:Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 351:145-147, 1991
3) Böhm M, Swedberg K, Komajda M, et al:Heart rate as a risk factor in chronic heart failure(SHIFT):the association between heart rate and outcomes in a randomised placebo-controlled trial. Lancet 376:886-894, 2010
4) Bleeker WK, Mackaay AJ, Masson-Pévet M, et al:Functional and morphological organization of the rabbit sinus node. Circ Res 46:11-22, 1980
5) Edelberg JM, Aird WC, Rosenberg RD:Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J Clin Invest 101:337-343, 1998
6) Miake J, Marban E, Nuss HB:Biological pacemaker created by gene transfer. Nature 419:132-133, 2002
7) Qu J, Plotnikov AN, Danilo P, et al:Expression and function of a biological pacemaker in canine heart. Circulation 107:1106-1109, 2003
8) Takahashi K, Yamanaka S:Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676, 2006
9) Ieda M, Fu JD, Delgado-Olguin P, et al:Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142:375-386, 2010
10) Kapoor N, Liang W, Marban E, et al:Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol 31:54-62, 2013
11) Hu YF, Dawkins JF, Cho HC, et al:Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block. Sci Transl Med 6:245ra94, 2014
12) Dawkins JF, Hu YF, Valle J, et al:Antegrade Conduction Rescues Right Ventricular Pacing-Induced Cardiomyopathy in Complete Heart Block. J Am Coll Cardiol 73:1673-1687, 2019
13) van Weerd JH, Christoffels VM:The formation and function of the cardiac conduction system. Development 143:197-210, 2016
14) Ruhparwar A, Tebbenjohanns J, Niehaus M, et al:Transplanted fetal cardiomyocytes as cardiac pacemaker. Eur J Cardiothorac Surg 21:853-857, 2002
15) Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al:Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147, 1998
16) Kehat I, Khimovich L, Caspi O, et al:Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22:1282-1289, 2004
17) Xue T, Cho HC, Akar FG, et al:Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes:insights into the development of cell-based pacemakers. Circulation 111:11-20, 2005
18) Plotnikov AN, Shlapakova I, Szabolcs MJ, et al:Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart. Circulation 116:706-713, 2007
19) Chauveau S, Anyukhovsky EP, Ben-Ari M, et al:Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function. Circ Arrhythm Electrophysiol 10:e004508, 2017
20) Menasché P, Vanneaux V, Hagège A, et al:Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction. J Am Coll Cardiol 71:429-438, 2018
21) Chong JJ, Yang X, Don CW, et al:Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature 510:273-277, 2014
22) Shiba Y, Gomibuchi T, Seto T, et al:Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts. Nature 538:388-391, 2016
23) Liu YW, Chen B, Yang X, et al:Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates. Nat Biotechnol 36:597-605, 2018
24) Romagnuolo R, Masoudpour H, Porta-Sànchez A, et al:Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias. Stem Cell Reports 12:967-981, 2019
25) Zhu WZ, Xie Y, Moyes KW, et al:Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells. Circ Res 107:776-786, 2010
26) Schweizer PA, Darche FF, Ullrich ND, et al:Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Stem Cell Res Ther 8:229, 2017
27) Birket MJ, Ribeiro MC, Verkerk AO, et al:Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Nat Biotechnol 33:970-979, 2015
28) Protze SI, Liu J, Nussinovitch U, et al:Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nat Biotechno 35:56-68, 2017
29) Zhang JZ, Termglinchan V, Shao NY, et al:A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Cell Stem Cell 24:802-811.2019
30) Citro L, Naidu S, Hassan F, et al:Comparison of human induced pluripotent stem-cell derived cardiomyocytes with human mesenchymal stem cells following acute myocardial infarction. PLoS One 9:e116281, 2014
31) Mandai M, Watanabe A, Kurimoto Y, et al:Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med 376:1038-1046, 2017

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2432-3292

印刷版ISSN:2432-3284

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?